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Your search keyword '"Lew, MF"' showing total 2 results
Start Over Author "Lew, MF" Journal american journal of psychiatry
2 results on '"Lew, MF"'

1. Psychopharmacologic and clinical correlates of attention in chronic schizophrenia.

Author

Strauss ME, Lew MF, Coyle JT, and Tune LE

Subjects
Adult, Ambulatory Care, Basal Ganglia Diseases chemically induced, Basal Ganglia Diseases drug therapy, Female, Humans, Male, Middle Aged, Parasympatholytics blood, Parasympatholytics pharmacology, Psychomotor Performance drug effects, Psychotropic Drugs adverse effects, Psychotropic Drugs blood, Reaction Time drug effects, Attention drug effects, Psychotropic Drugs pharmacology, Schizophrenia drug therapy, Schizophrenic Psychology
Abstract

Distractibility and reaction time were measured in 25 clinically stable chronic schizophrenic subjects receiving psychotropic medications. Higher serum neuroleptic levels were associated with lessened distractibility. Extrapyramidal side effects and level of symptoms were each related to slow and variable reaction times.

Published
1985
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2. Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients.

Author

Tune LE, Strauss ME, Lew MF, Breitlinger E, and Coyle JT

Subjects
Adult, Ambulatory Care, Antipsychotic Agents adverse effects, Antipsychotic Agents therapeutic use, Female, Humans, Male, Middle Aged, Parasympatholytics pharmacology, Parasympatholytics therapeutic use, Schizophrenia drug therapy, Antipsychotic Agents blood, Memory drug effects, Parasympatholytics blood, Schizophrenia blood, Schizophrenic Psychology
Abstract

The authors tested working or recent memory in 24 stabilized schizophrenic outpatients who were taking psychotropic medication. Memory performance did not correlate with severity of schizophrenic symptoms, verbal IQ, or serum neuroleptic levels, but there was a significant inverse correlation between serum anticholinergic levels and performance on the memory task. The results suggest that therapeutic doses of anticholinergics may cause subtle impairments of cognitive functions.

Published
1982
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