1. Altered cord serum 25‐hydroxyvitamin D signaling and placental inflammation is associated with pre‐term birth
- Author
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Priyanka Verma, Singh Rajender, Kiran Singh, Shreshtha Gupta, Rachna Verma, Sangeeta Rai, and Snehil Budhwar
- Subjects
Adult ,medicine.medical_specialty ,Placenta Diseases ,Cord ,Immunology ,Gestational Age ,Inflammation ,Calcitriol receptor ,Pregnancy ,Internal medicine ,Placenta ,medicine ,Vitamin D and neurology ,Birth Weight ,Humans ,Immunology and Allergy ,RNA, Messenger ,Vitamin D ,25-Hydroxyvitamin D3 1-alpha-Hydroxylase ,Fetus ,business.industry ,Transcription Factor RelA ,Infant ,Obstetrics and Gynecology ,Gestational age ,Fetal Blood ,Vitamin D Deficiency ,medicine.disease ,Pregnancy Complications ,medicine.anatomical_structure ,Endocrinology ,Reproductive Medicine ,Premature Birth ,Receptors, Calcitriol ,Female ,Chorionic Villi ,Inflammation Mediators ,medicine.symptom ,business ,Infant, Premature - Abstract
PROBLEM Vitamin D is well-known for having anti-inflammatory and immunomodulatory properties. Impaired maternal vitamin D status has been known to increase the risk of adverse pregnancy outcomes like pre-term birth. The present study aims to evaluate the impact of fetal cord serum 25-hydroxyvitamin D-mediated signaling in mediating inflammatory responses in placenta during pre-term birth. METHOD OF STUDY For the above purpose, cord serum 25 hydroxyvitamin D 25(OH)D were measured in term (n = 20) and pre-term (n = 20) born babies using ELISA. Vitamin D downstream signaling has also been checked in placenta (VDR, CYP27B1, cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, p-NF-kappaB) using Western blotting and immunohistochemistry. Pearson correlation model was used to do correlation study. RESULTS Compared with term born babies (59.31 ± 3.476), decline in cord serum 25(OH)D levels is observed in pre-term born babies (22.26 ± 1.083, P =
- Published
- 2019
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