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An editorial is presented on the impaired function of alveolar macrophages (AMs) in individuals with chronic obstructive pulmonary disease (COPD) due to defective phagocytosis and efferocytosis. An overview of the study conducted by Ryan and colleagues that has been published in the American Journal of Respiratory and Critical Care Medicine is presented. It further examines the metabolic pathways that govern macrophage adaptation and responses to various environmental signals.