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Your search keyword '"Christine M. Freeman"' showing total 11 results
Start Over Author "Christine M. Freeman" Journal american journal of respiratory and critical care medicine
11 results on '"Christine M. Freeman"'

2. Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

Author

Russell G. Buhr, Igor Z. Barjaktarevic, P. Miguel Quibrera, Lori A. Bateman, Eugene R. Bleecker, David J. Couper, Jeffrey L. Curtis, Brett A. Dolezal, MeiLan K. Han, Nadia N. Hansel, Jerry A. Krishnan, Fernando J. Martinez, William McKleroy, Robert Paine, Stephen I. Rennard, Donald P. Tashkin, Prescott G. Woodruff, Richard E. Kanner, Christopher B. Cooper, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, R. Graham Barr, Surya P. Bhatt, Richard C. Boucher, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig Galban, Annette T. Hastie, Eric A. Hoffman, Yvonne Huang, Robert J. Kaner, Eric C. Kleerup, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura Paulin, Stephen P. Peters, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Wanda K. O’Neal, Victor E. Ortega, Sanjeev Raman, J. Michael Wells, and Robert A. Wise

Subjects
Airway Obstruction, Cohort Studies, Pulmonary and Respiratory Medicine, Pulmonary Disease, Chronic Obstructive, Spirometry, Forced Expiratory Volume, Vital Capacity, Humans, Critical Care and Intensive Care Medicine, Asthma, Bronchodilator Agents
Published
2022

3. Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease

Author

Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, Lori A. Bateman, Surya P. Bhatt, Eugene R. Bleecker, Richard C. Boucher, Stephanie A. Christenson, Gerard J. Criner, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Craig Galban, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Richard E. Kanner, Eric C. Kleerup, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura Paulin, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Wanda K. O’Neal, Sanjeev Raman, Stephen I. Rennard, Donald P. Tashkin, J. Michael Wells, and Robert A. Wise

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published
2022

5. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality

Author

George T. O'Connor, Mizuki Nishino, Joanne M. Murabito, Hiroto Hatabu, Jason L. Sanders, Vasan S. Ramachandran, Daniel L. Levy, Josée Dupuis, Emelia J. Benjamin, Russell P. Bowler, Gary M. Hunninghake, Jeffrey L. Curtis, George R. Washko, Hanfei Xu, Rachel K. Putman, Tetsuro Araki, and Christine M. Freeman

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Aging, Pathology, medicine.medical_specialty, Growth Differentiation Factor 15, Critical Care and Intensive Care Medicine, Idiopathic pulmonary fibrosis, Odds Ratio, Humans, Medicine, Longitudinal Studies, Aged, Lung, business.industry, Age Factors, Middle Aged, respiratory system, medicine.disease, Survival Rate, medicine.anatomical_structure, Female, GDF15, Lung Diseases, Interstitial, business, Biomarkers
Abstract

Rationale: The association between aging and idiopathic pulmonary fibrosis has been established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not...

Published
2021

6. The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

Author

Victor E. Ortega, Xingnan Li, Wanda K. O’Neal, Lela Lackey, Elizabeth Ampleford, Gregory A. Hawkins, Philip J. Grayeski, Alain Laederach, Igor Barjaktarevic, R. Graham Barr, Christopher Cooper, David Couper, MeiLan K. Han, Richard E. Kanner, Eric C. Kleerup, Fernando J. Martinez, Robert Paine, Stephen P. Peters, Cheryl Pirozzi, Stephen I. Rennard, Prescott G. Woodruff, Eric A. Hoffman, Deborah A. Meyers, Eugene R. Bleecker, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, Lori A. Bateman, Surya P. Bhatt, Richard C. Boucher, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Ronald G. Crystal, Jeffrey L. Curtis, Claire M. Doerschuk, Mark T. Dransfield, Christine M. Freeman, Craig Galban, Nadia N. Hansel, Annette T. Hastie, Yvonne Huang, Robert J. Kaner, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Wendy C. Moore, Laura Paulin, Nirupama Putcha, Elizabeth C. Oelsner, Sanjeev Raman, Donald P. Tashkin, J. Michael Wells, and Robert A. Wise

Subjects
Pulmonary and Respiratory Medicine, business.industry, Heterozygote advantage, Serpin, Critical Care and Intensive Care Medicine, Molecular biology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Genotype, Pi, Medicine, 030212 general & internal medicine, business, Clade, Gene, Lung function
Abstract

Rationale: The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, me...

Published
2020

7. Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts

Author

Jason D. Keene, Sean Jacobson, Katerina Kechris, Gregory L. Kinney, Marilyn G. Foreman, Claire M. Doerschuk, Barry J. Make, Jeffrey L. Curtis, Stephen I. Rennard, R. Graham Barr, Eugene R. Bleecker, Richard E. Kanner, Eric C. Kleerup, Nadia N. Hansel, Prescott G. Woodruff, MeiLan K. Han, Robert Paine, Fernando J. Martinez, Russell P. Bowler, Wanda K. O’Neal, Neil E. Alexis, Wayne H. Anderson, Richard C. Boucher, Elizabeth E. Carretta, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Ronald G. Crystal, Mark T. Dransfield, Christine M. Freeman, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, John D. Newell, Elizabeth C. Oelsner, Nirupama Putcha, Donald P. Tashkin, Mary Beth Scholand, J. Michael Wells, and Robert A. Wise

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published
2020

8. It’s Complicated: Lung Dendritic Cells in Chronic Obstructive Pulmonary Disease

Author

Christine M. Freeman and Jeffrey L. Curtis

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung, business.industry, Extramural, MEDLINE, Pulmonary disease, Dendritic Cells, Critical Care and Intensive Care Medicine, Pulmonary Disease, Chronic Obstructive, Text mining, medicine.anatomical_structure, Humans, Medicine, business
Published
2020

9. Presence of Tropheryma whipplei in Different Body Sites in a Cohort of Healthy Subjects

Author

Alison Morris, Emily Clausen, Heather Michael, S. Qin, Lorrie Lucht, Christine M. Freeman, Jeffrey L. Curtis, and James M. Beck

Subjects
Adult, Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tropheryma, Critical Care and Intensive Care Medicine, Polymerase Chain Reaction, Gastroenterology, law.invention, Cohort Studies, Tropheryma whipplei, 03 medical and health sciences, Reference Values, law, Internal medicine, Correspondence, medicine, Humans, Polymerase chain reaction, biology, business.industry, Stomach, Healthy subjects, biology.organism_classification, 030104 developmental biology, Reference values, Cohort, Female, business, Bronchoalveolar Lavage Fluid, Cohort study
Published
2016

10. Lung Dendritic Cell Expression of Maturation Molecules Increases with Worsening Chronic Obstructive Pulmonary Disease

Author

MeiLan K. Han, Catherine A. Meldrum, Lisa McCloskey, Theresa M. Ames, Christine M. Freeman, Christi Getty, Stephen W. Chensue, Fernando J. Martinez, Douglas A. Arenberg, Jeffrey L. Curtis, and Jill C. Todt

Subjects
Antigens, Differentiation, T-Lymphocyte, CD4-Positive T-Lymphocytes, Male, Pulmonary and Respiratory Medicine, Cell Culture Techniques, B. Chronic Obstructive Pulmonary Disease, chemical and pharmacologic phenomena, Critical Care and Intensive Care Medicine, Severity of Illness Index, Pulmonary Disease, Chronic Obstructive, Antigens, CD, Intensive care, medicine, Humans, Lectins, C-Type, Lung, Aged, CD86, COPD, CD40, biology, business.industry, Smoking, Respiratory disease, Cell Differentiation, hemic and immune systems, Dendritic Cells, Dendritic cell, Middle Aged, Flow Cytometry, medicine.disease, respiratory tract diseases, Cross-Sectional Studies, medicine.anatomical_structure, Immunology, biology.protein, Female, business, CD80
Abstract

Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis.To determine the expression of maturation molecules by individual DC subsets in relationship to COPD stage and to expression of the acute activation marker CD69 by lung CD4(+) T cells.We nonenzymatically released lung leukocytes from human surgical specimens (n = 42) and used flow cytometry to identify three DC subsets (mDC1, mDC2, and pDC) and to measure their expression of three costimulatory molecules (CD40, CD80 and CD86) and of CD83, the definitive marker of DC maturation. Spearman nonparametric correlation analysis was used to identify significant correlations between expression of DC maturation molecules and COPD severity.Expression of CD40 by mDC1 and mDC2 and of CD86 by mDC2 was high regardless of GOLD stage, but CD80 and CD83 on these two DC subsets increased with disease progression. pDC also showed significant increases in expression of CD40 and CD80. Expression of all but one of the DC molecules that increased with COPD severity also correlated with CD69 expression on lung CD4(+) T cells from the same patients, with the exception of CD83 on mDC2.This cross-sectional study implies that COPD progression is associated with significant increases in costimulatory molecule expression by multiple lung DC subsets. Interactions with lung DCs may contribute to the immunophenotype of CD4(+) T cells in advanced COPD. Clinical trial registered with www.clinicaltrials.gov (NCT00281229).

Published
2009

11. 'B' for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease

Author

Jeffrey L. Curtis, Gary B. Huffnagle, and Christine M. Freeman

Subjects
Pulmonary and Respiratory Medicine, Male, Pathology, medicine.medical_specialty, Lymphoid Tissue, Adaptive Immunity, Critical Care and Intensive Care Medicine, Pulmonary Disease, Chronic Obstructive, Parenchyma, B-Cell Activating Factor, medicine, Animals, Humans, B-cell activating factor, Lung, COPD, B-Lymphocytes, biology, business.industry, Germinal center, respiratory system, medicine.disease, Acquired immune system, respiratory tract diseases, medicine.anatomical_structure, Lymphatic system, Immunology, biology.protein, Female, Antibody, business
Abstract

Lymphoid neogenesis, the formation of tertiary lymphoid structures (1), within distal lung parenchyma indisputably characterizes advanced chronic obstructive pulmonary disease (COPD) (2, 3). Many such lung lymphoid follicles (LLFs) contain germinal centers, indicating immunoglobulin class-switching. Some LLFs in advanced COPD produce auto-antibodies that could fuel lung destruction (4, 5). These findings make lung B cells highly suspicious, especially when congregating in LLF.

Published
2015

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