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Your search keyword '"James D, West"' showing total 3 results
Start Over Author "James D, West" Journal american journal of respiratory and critical care medicine
3 results on '"James D, West"'

1. Molecular Function and Contribution of TBX4 in Development and Disease

Author

Justyna A. Karolak, Carrie L. Welch, Christian Mosimann, Katarzyna Bzdęga, James D. West, David Montani, Mélanie Eyries, Mary P. Mullen, Steven H. Abman, Matina Prapa, Stefan Gräf, Nicholas W. Morrell, Anna R. Hemnes, Frédéric Perros, Rizwan Hamid, Malcolm P. O. Logan, Jeffrey Whitsett, Csaba Galambos, Paweł Stankiewicz, Wendy K. Chung, and Eric D. Austin

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published
2023
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2. Thromboxane-Prostanoid Receptor Signaling Drives Persistent Fibroblast Activation in Pulmonary Fibrosis

Author

Toshio Suzuki, Jonathan A. Kropski, Jingyuan Chen, Erica J. Carrier, Xinping Chen, Taylor P. Sherrill, Nichelle I. Winters, Jane E. Camarata, Vasiliy V. Polosukhin, Wei Han, Anandharajan Rathinasabapathy, Sergey Gutor, Peter Gulleman, Carleen Sabusap, Nicholas E. Banovich, Harikrishna Tanjore, Michael L. Freeman, Yuji Tada, Lisa R. Young, Jason J. Gokey, Timothy S. Blackwell, and James D. West

Subjects
Pulmonary and Respiratory Medicine, F2-Isoprostanes, Receptors, Thromboxane, Thromboxanes, Fibroblasts, Critical Care and Intensive Care Medicine, Idiopathic Pulmonary Fibrosis, Mice, Inbred C57BL, Bleomycin, Mice, Transforming Growth Factor beta, Prostaglandins, Animals, Humans, Lung
Published
2023

3. Molecular Function and Contribution of

Author

Justyna A, Karolak, Carrie L, Welch, Christian, Mosimann, Katarzyna, Bzdega, James D, West, David, Montani, Mélanie, Eyries, Mary P, Mullen, Steven H, Abman, Matina, Prapa, Stefan, Gräf, Nicholas W, Morrell, Anna R, Hemnes, Frédéric, Perros, Rizwan, Hamid, Malcolm P O, Logan, Jeffrey, Whitsett, Csaba, Galambos, Paweł, Stankiewicz, Wendy K, Chung, and Eric D, Austin

Abstract

Over the past decade recognition of the profound impact of the T-box 4 (TBX4) gene, which encodes a member of the evolutionarily conserved family of T-box-containing transcription factors, upon respiratory diseases has emerged. The developmental importance of TBX4 is emphasized by the association of TBX4 variants with congenital disorders involving respiratory and skeletal structures; however, the exact role of TBX4 in human development remains incompletely understood. Here, we discuss the developmental, tissue-specific, and pathological TBX4 functions identified through human and animal studies and review the published TBX4 variants resulting in variable disease phenotypes. We also outline future research directions to fill the gaps in our understanding of TBX4 function and of how TBX4 disruption impacts development.

Published
2022

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