1. The Airway Longitudinal Elastic Fiber Network and Mucosal Folding in Patients with Asthma
- Author
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Steven F. Perry, Alan James, John C. Butt, Artee Karkhanis, Francis H. Y. Green, Salima Harji, and N. Carroll
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Bronchi ,Critical Care and Intensive Care Medicine ,medicine ,Humans ,In patient ,Asthma ,Bronchus ,Mucous Membrane ,business.industry ,Smoking ,Respiratory disease ,Histology ,Fibroblasts ,respiratory system ,Elastic Tissue ,medicine.disease ,respiratory tract diseases ,medicine.anatomical_structure ,Female ,Collagen ,business ,Airway ,Myofibroblast ,Elastic fiber - Abstract
A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds.
- Published
- 2000