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Sharing of individual participant data is encouraged by the International Committee of Medical Journal Editors. We analyzed clinical trial registry data from ClinicalTrials.gov (CTG) and determined the proportion of trials sharing de-identified Individual Participant Data (IPD). We looked at 3,138 medical conditions (as Medical Subject Heading terms). Overall, 10.8% of trials with first registration date after December 1, 2015 answered 'Yes' to plan to share de-identified IPD data. This sharing rate ranges between 0% (biliary tract neoplasms) to 72.2% (meningitis, meningococcal) when analyzed by disease that is focus of a study. Via a predictive model, we found that studies that deposited basic summary results data to CTG results registry, large studies and phase 3 interventional studies are most likely to declare intent to share IPD data. As part of an HIV common data element analysis project, we further compared a body of HIV trials (24% sharing rate) to other diseases., (©2019 AMIA - All rights reserved.)

Value sets are essential in activities such as electronic clinical quality measures (eCQM) and patient cohort definition. Creation and maintenance of value sets is labor intensive and error prone. Our method aims to use existing inter-terminology maps to improve the quality of value sets that are defined in more than one terminology. For 197 eCQM value sets defined in SNOMED CT plus ICD-9-CM and/or ICD-10-CM, the map-generated codes showed good overlap with the value set codes. Manual review showed that some new codes identified by mapping should probably be included in the value sets. This could potentially augment the ICD-9-CM codes by 45% (1.5 codes), ICD-10-CM codes by 25% (1.8 codes) and SNOMED CT codes by up to 42% (4.8 codes) per value set on average. The mapping between SNOMED CT and ICD-10-PCS did not perform as well because of the granularity discrepancy in the map., (©2019 AMIA - All rights reserved.)

This paper focuses on value sets as an essential component in the health analytics ecosystem. We discuss shared repositories of reusable value sets and offer recommendations for their further development and adoption. In order to motivate these contributions, we explain how value sets fit into specific analytic tasks and the health analytics landscape more broadly; their growing importance and ubiquity with the advent of Common Data Models, Distributed Research Networks, and the availability of higher order, reusable analytic resources like electronic phenotypes and electronic clinical quality measures; the formidable barriers to value set reuse; and our introduction of a concept-agnostic orientation to vocabulary collections. The costs of ad hoc value set management and the benefits of value set reuse are described or implied throughout. Our standards, infrastructure, and design recommendations are not systematic or comprehensive but invite further work to support value set reuse for health analytics. The views represented in the paper do not necessarily represent the views of the institutions or of all the co-authors .

We present a method that extracts medication information from discharge summaries. The program relies on parsing rules written as a set of regular expressions and on a user-configurable drug lexicon. Our evaluation shows a precision of 94% and recall of 83% in the extraction of medication information. We use a broader definition of medication information than previous studies, including drug names appearing with and without dosage information, misspelled drug names, and contextual information.