Search

Your search keyword '"Gerrit Stoter"' showing total 3 results
Start Over Author "Gerrit Stoter" Journal amino acids
3 results on '"Gerrit Stoter"'

1. Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients

Author

A.M.M. Eggermont, A. R. Van Gool, Paul G.H. Mulder, Wim H. J. Kruit, Gerrit Stoter, Stefan Sleijfer, Durk Fekkes, Marjolein Bannink, Neurosciences, Psychiatry, Medical Oncology, Epidemiology, and Surgery

Subjects
Male, medicine.medical_specialty, Time Factors, Arginine, Clinical Biochemistry, Pegylated interferon α, Interferon alpha-2, Nitric Oxide, Biochemistry, Antiviral Agents, Nitric oxide, Polyethylene Glycols, chemistry.chemical_compound, Interferon, Risk Factors, Internal medicine, medicine, Citrulline, Humans, Melanoma, Maintenance dose, business.industry, Organic Chemistry, Interferon-alpha, Plasma levels, medicine.disease, Recombinant Proteins, Endocrinology, chemistry, Immunology, Female, business, medicine.drug
Abstract

The aim of this study was to evaluate the effect of pegylated interferon-alpha (PEG-IFN-alpha) on the plasma citrulline/arginine ratio, regarded as an index of nitric oxide (NO) synthesis, in patients with high-risk melanoma. Forty patients were randomly assigned to either PEG-IFN-alpha treatment (n = 22) or to observation only (control group, n = 18). The treatment group received 6 microg PEG-IFN-alpha/kg once a week during 8 weeks, followed by a maintenance dose of 3 microg/kg/wk. Blood was collected at different time points, plasma concentrations of citrulline and arginine were measured and the ratio of citrulline/arginine was calculated. Patients treated with PEG-IFN-alpha showed a significant decrease in the concentrations of citrulline and in the citrulline/arginine ratio during the whole study period, both compared to baseline values and to the control group. The data suggest that therapy with PEG-IFN-alpha results in a marked decrease in the synthesis of NO in melanoma patients.

Published
2005

2. Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-α therapy.

Author

Marjolein Bannink, Stefan Sleijfer, Wim Kruit, Bronno van der Holt, Alexander Eggermont, Michiel Hengeveld, and Gerrit Stoter

Subjects
CANCER patients, NITRIC oxide, MONOAMINE oxidase, INTERFERONS, BIOGENIC amines, CANCER treatment, BLOOD testing, PATHOLOGICAL psychology
Abstract

Abstract  Both increased and decreased nitric oxide (NO) synthesis have been reported in patients treated with interferon-α (IFN-α). Animal studies showed that IFN-α administration results in increased levels of biogenic amines, subsequent activation of monoamine oxidases (MAOs), and finally in a change in NO production due to the H2O2 generated by MAOs. We examined the potential relationship between NO production in plasma and MAO-B activity in platelets of 43 cancer patients during 8 weeks of treatment with IFN-α. NO synthesis was quantitated by measuring both the ratio of citrulline and arginine (CIT/ARG-ratio) and total nitrite/nitrate (NOx) levels. Compared to baseline, MAO activity and NOx increased, while the CIT/ARG-ratio decreased. No associations were found between NOx, MAO and CIT/ARG-ratio. Only few associations were observed between changes in the biochemical parameters and changes in psychopathology induced by IFN-α, of which the association between changes in CIT and lassitude was the most consistent. The results suggest that peripheral NO production and MAO activity are unrelated to each other, and that peripheral changes in these biochemical parameters induced by IFN-α are unlikely to contribute to definite psychiatric disturbance. [ABSTRACT FROM AUTHOR]

Published
2009

3. Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-α therapy

Author

Alexander M.M. Eggermont, Stefan Sleijfer, Durk Fekkes, Wim H. J. Kruit, Arthur R. Van Gool, Bronno van der Holt, Michiel W. Hengeveld, Marjolein Bannink, Gerrit Stoter, Neurosciences, Psychiatry, Medical Oncology, Hematology, and Surgery

Subjects
Adult, Blood Platelets, Male, medicine.medical_specialty, Skin Neoplasms, Arginine, Monoamine oxidase, Clinical Biochemistry, Alpha interferon, Biology, Biochemistry, Nitric oxide, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Citrulline, Humans, Platelet, Prospective Studies, Nitrite, Carcinoma, Renal Cell, Melanoma, Nitrites, Cancer, Aged, Nitrates, Depression, Organic Chemistry, Interferon-alpha, Middle Aged, Kidney Neoplasms, Monoamine neurotransmitter, Endocrinology, chemistry, Original Article, Female, Interferon-α
Abstract

Both increased and decreased nitric oxide (NO) synthesis have been reported in patients treated with interferon-alpha (IFN-alpha). Animal studies showed that IFN-alpha administration results in increased levels of biogenic amines, subsequent activation of monoamine oxidases (MAOs), and finally in a change in NO production due to the H(2)O(2) generated by MAOs. We examined the potential relationship between NO production in plasma and MAO-B activity in platelets of 43 cancer patients during 8 weeks of treatment with IFN-alpha. NO synthesis was quantitated by measuring both the ratio of citrulline and arginine (CIT/ARG-ratio) and total nitrite/nitrate (NOx) levels. Compared to baseline, MAO activity and NOx increased, while the CIT/ARG-ratio decreased. No associations were found between NOx, MAO and CIT/ARG-ratio. Only few associations were observed between changes in the biochemical parameters and changes in psychopathology induced by IFN-alpha, of which the association between changes in CIT and lassitude was the most consistent. The results suggest that peripheral NO production and MAO activity are unrelated to each other, and that peripheral changes in these biochemical parameters induced by IFN-alpha are unlikely to contribute to definite psychiatric disturbance.

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results