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7 results on '"Longobardo, Luigi"'

4. Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families.

Author

Longobardo, Luigi, Cecere, Nunzia, DellaGreca, Marina, and Paola, Ivan

Subjects
*THIOLS, *SULFIDES, *AMINO acids, *CYSTATHIONINE, *HOMOCYSTEINE, *CYSTEINE
Abstract

Natural l-homocysteine and l,l-cystathionine, along with a series of unnatural analogues, have been prepared from l-aspartic and l-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of l-cysteine and potassium thioacetate. [ABSTRACT FROM AUTHOR]

Published
2013
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5. Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families

Author

Luigi Longobardo, Nunzia Cecere, Marina DellaGreca, Ivan de Paola, Longobardo, Luigi, Nunzia, Cecere, DELLA GRECA, Marina, and Ivan de, Paola

Subjects
chemistry.chemical_classification, Aspartic Acid, Molecular Structure, biology, Homocysteine, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Glutamic Acid, chemistry.chemical_element, Biochemistry, Cystathionine beta synthase, Sulfur, Amino acid, chemistry.chemical_compound, Cystathionine, Thioether, Nucleophile, Aspartic acid, biology.protein, Thiol
Abstract

Natural L-homocysteine and L,L-cystathionine, along with a series of unnatural analogues, have been prepared from L-aspartic and L-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of L-cysteine and potassium thioacetate.

Published
2012
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6. Novel sulfur and selenium containing bis-alpha-amino acids from 4-hydroxyproline

Author

Romualdo Caputo, Ivan de Paola, Marina DellaGreca, Luigi Longobardo, Domenico Mastroianni, Caputo, Romualdo, DELLA GRECA, Marina, I., de PAOLA, D., Mastroianni, and Longobardo, Luigi

Subjects
inorganic chemicals, Cysteine thioalkylation, Stereochemistry, Clinical Biochemistry, chemistry.chemical_element, Selenocystine, 4-Substituted proline, Biochemistry, Hydroxyproline, chemistry.chemical_compound, Residue (chemistry), Selenium, Peptide bond, Organic chemistry, Proline, Cysteine, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Stereoisomerism, Sulfur, Amino acid, Bis-α-amino acid, chemistry, Unnatural amino acids
Abstract

The synthesis of new substituted prolines carrying at C-4 a second alpha-amino acid residue is reported. The amino acid, L-cysteine or L-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively. The products were prepared with different stereochemistry at C-4, in few and clean high-yielding steps, with suitable protections for solid phase applications. The introduction of both sulfur and selenium atoms at C-4 of the proline ring seems to enhance significantly the cis geometry at the prolyl amide bond.

Published
2008

7. Novel sulfur and selenium containing bis-alpha-amino acids from 4-hydroxyproline.

Author

Caputo R, Dellagreca M, de Paola I, Mastroianni D, and Longobardo L

Subjects
Hydroxyproline chemical synthesis, Molecular Structure, Stereoisomerism, Cysteine chemistry, Hydroxyproline chemistry, Selenium chemistry, Sulfur chemistry
Abstract

The synthesis of new substituted prolines carrying at C-4 a second alpha-amino acid residue is reported. The amino acid, L-cysteine or L-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively. The products were prepared with different stereochemistry at C-4, in few and clean high-yielding steps, with suitable protections for solid phase applications. The introduction of both sulfur and selenium atoms at C-4 of the proline ring seems to enhance significantly the cis geometry at the prolyl amide bond.

Published
2010
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