24 results on '"Diclofenac administration & dosage"'
Search Results
2. Co-administering diclofenac with intravenous paracetamol or Hartmann's solution.
- Author
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Madden GB
- Subjects
- Drug Combinations, Humans, Infusions, Intravenous, Off-Label Use, Ringer's Lactate, Acetaminophen administration & dosage, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Isotonic Solutions administration & dosage
- Published
- 2014
- Full Text
- View/download PDF
3. A randomised controlled trial of two analgesic techniques for paediatric tonsillectomy*.
- Author
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Rawlinson E, Walker A, Skone R, Thillaivasan A, and Bagshaw O
- Subjects
- Acetaminophen therapeutic use, Analgesics therapeutic use, Analgesics, Opioid administration & dosage, Anesthetics, Inhalation, Anesthetics, Intravenous, Anti-Inflammatory Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Antiemetics therapeutic use, Child, Child, Preschool, Codeine administration & dosage, Codeine therapeutic use, Dexamethasone therapeutic use, Diclofenac administration & dosage, Double-Blind Method, Female, Fentanyl administration & dosage, Humans, Male, Methyl Ethers, Ondansetron therapeutic use, Pain Measurement drug effects, Postoperative Nausea and Vomiting epidemiology, Postoperative Nausea and Vomiting prevention & control, Propofol, Sample Size, Sevoflurane, Analgesics, Opioid therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Diclofenac therapeutic use, Fentanyl therapeutic use, Pain, Postoperative drug therapy, Tonsillectomy
- Abstract
Investigators from Bristol described a fentanyl- and diclofenac-based analgesic technique for tonsillectomy with low postoperative nausea and vomiting rates and low pain scores. This study compared the effectiveness of a modified Bristol technique with a codeine-based regimen with respect to PONV and analgesia. Sixty-five children, ASA 1-2, were randomly assigned to either the Bristol group (fentanyl 1-2 μg.kg(-1) and diclofenac 1-2 mg.kg(-1)) or codeine group (codeine 1.5 mg.kg(-1)). All children received paracetamol 15 mg.kg(-1) and dexamethasone 0.1 mg.kg(-1) . Postoperative nausea and vomiting and pain scores were recorded hourly, and fitness for discharge was assessed at 4 h. The overall incidence of postoperative nausea and vomiting was 21% with no difference between groups (Bristol group 8/30, codeine group 5/32, p = 0.29). Children in the Bristol group required analgesia earlier than those in the codeine group (p < 0.005), but maximum pain scores were not different (Bristol group median (IQR [range) 4.5 (3-5 [0-5]), codeine group 4.0 (2-5 [1-5]), p = 0.15). Twenty-three per cent of children were assessed as not fit for discharge at 4 h. The codeine-based regimen may have a small advantage over the Bristol regimen, but neither technique seems ideally suited for a day-case service without a longer period of observation. You can respond to this article at http://www.anaesthesiacorrespondence.com., (© 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.)
- Published
- 2011
- Full Text
- View/download PDF
4. Pre-operative analgesia with rectal diclofenac and/or paracetamol in children undergoing inguinal hernia repair.
- Author
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Riad W and Moussa A
- Subjects
- Acetaminophen administration & dosage, Administration, Rectal, Analgesics, Non-Narcotic administration & dosage, Analgesics, Opioid administration & dosage, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Blood Pressure drug effects, Child, Child, Preschool, Diclofenac administration & dosage, Double-Blind Method, Drug Administration Schedule, Drug Combinations, Female, Heart Rate drug effects, Humans, Male, Morphine administration & dosage, Pain Measurement methods, Preanesthetic Medication methods, Acetaminophen therapeutic use, Analgesics, Non-Narcotic therapeutic use, Diclofenac therapeutic use, Hernia, Inguinal surgery, Pain, Postoperative prevention & control
- Abstract
Both rectal diclofenac and paracetamol are commonly used to treat acute postoperative pain in children but combining them to improve the quality of analgesia is controversial. This study aimed to detect whether the pre-operative combined administration of rectal diclofenac and paracetamol is superior to either drug alone. One hundred and eight patients were randomly assigned to receive either rectal diclofenac 1 mg.kg(-1) or paracetamol 40 mg.kg(-1) or their combination 1 h prior to surgery. In the first 24 h postoperatively, pain was assessed using the Wong and Baker Pain Scale. If the patients experienced a pain score of 2 or more, morphine was given. The total dose of morphine and number of doses required were recorded. Children who received the rectal diclofenac-paracetamol combination experienced a lower pain scale and a decreased need for morphine compared with children receiving each drug alone.
- Published
- 2007
- Full Text
- View/download PDF
5. Enteral drugs given through a central venous catheter.
- Author
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Nicholson Roberts TC and Swart M
- Subjects
- Aged, Anti-Arrhythmia Agents adverse effects, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Diclofenac administration & dosage, Diclofenac adverse effects, Female, Humans, Postoperative Care adverse effects, Verapamil administration & dosage, Verapamil adverse effects, Anti-Arrhythmia Agents administration & dosage, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Catheterization, Central Venous, Intubation, Gastrointestinal, Medication Errors, Respiratory Insufficiency chemically induced
- Abstract
A 74-year-old lady was given verapamil oral solution and a diclofenac dispersible tablet through her subclavian central venous catheter instead of her nasogastric tube five days after major head and neck surgery. The ensuing respiratory arrest resulting from profound ventilation-perfusion mismatch was made harder to manage by her potentially difficult airway. Information about the management of enteral drugs inadvertently given intravenously is sparse, and this sort of misrouting error is likely to be underreported. This case highlights the ease with which enteral preparations can be given by the wrong route.
- Published
- 2007
- Full Text
- View/download PDF
6. Evaluation of a diclofenac transdermal patch for the attenuation of venous cannulation pain: a prospective, randomised, double-blind, placebo-controlled study.
- Author
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Agarwal A, Dhiraaj S, Kumar A, Singhal V, and Singh U
- Subjects
- Administration, Cutaneous, Adolescent, Adult, Buttocks, Double-Blind Method, Female, Hand, Humans, Male, Middle Aged, Pain etiology, Pain Measurement methods, Prospective Studies, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Pain prevention & control, Phlebotomy adverse effects
- Abstract
Venous cannulation, although a minor procedure, is often painful. The present study was planned to evaluate the efficacy of a diclofenac transdermal patch placed over the venepuncture site in decreasing the pain of cannulation. Seventy-two adults undergoing elective surgery were included in this randomised, prospective, double-blind, placebo-controlled study. Patients were divided into three equal groups. The Control group had a placebo adhesive patch placed on the both the dorsum of hand and the buttock; the Diclofenac-Buttock group had a placebo patch placed on the dorsum of the hand and a diclofenac transdermal patch on the buttock; the Diclofenac-Hand group had a diclofenac transdermal patch placed on the dorsum of hand and a placebo patch on the buttock. The patches were applied 1 h before cannulation. An 18G cannula was used for all venous cannulations. Pain during cannulation was assessed on a non-graduated 10-cm visual analogue scale. Median [interquartile range] pain scores were 3.0 [2.0-4.0] in the Diclofenac-Hand group, 5.0 [4.3-7.8] in the Diclofenac-Buttock group and 6.5 [4.5-7.0] in the Control group, p < 0.05. The numbers needed to treat were six and two in the Diclofenac-Buttock and Diclofenac-Hand groups, respectively. The application of a diclofenac transdermal patch at the cannulation site appears to be effective in decreasing cannulation pain.
- Published
- 2006
- Full Text
- View/download PDF
7. High-dose intrathecal diamorphine for analgesia after Caesarean section.
- Author
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Stacey R, Jones R, Kar G, and Poon A
- Subjects
- Administration, Rectal, Adult, Analgesia, Patient-Controlled statistics & numerical data, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Chi-Square Distribution, Diclofenac administration & dosage, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Humans, Injections, Spinal, Pain Measurement, Pregnancy, Statistics, Nonparametric, Treatment Outcome, Analgesia, Obstetrical methods, Analgesics, Opioid administration & dosage, Cesarean Section methods, Heroin administration & dosage
- Abstract
Forty women undergoing elective Caesarean section under spinal anaesthesia using hyperbaric 0.5% bupivacaine were randomly allocated to receive either 0.5 mg or 1 mg intrathecal diamorphine. All women received diclofenac 100 mg at the end of surgery and morphine via a patient-controlled analgesia system. Oral analgesics were not used. Postoperative analgesia was more prolonged and more reliable in the 1-mg group. Mean time to first analgesia was 10.2 h in the 1-mg group and 6.9 h in the 0.5-mg group, and 45% in the 1-mg group used no morphine, compared with 10% in the 0.5-mg group. Mean morphine consumption over 24 h was 5.2 mg in the 1-mg group and 10.6 mg in the 0.5-mg group. Pain scores all tended to be lower in the 1-mg group but this was only significant at 4 h. There were no serious side-effects. Minor side-effects were common but well tolerated, and the incidence did not differ between the groups. If intrathecal diamorphine is used in combination with rectal diclofenac and without oral analgesia, then 1 mg provides superior analgesia to 0.5 mg without any worsening of the side-effects.
- Published
- 2001
- Full Text
- View/download PDF
8. Oral versus rectal diclofenac for postoperative tonsillectomy pain in children.
- Author
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Swanepoel A and Semple P
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Pain, Postoperative drug therapy, Tonsillectomy
- Published
- 1999
- Full Text
- View/download PDF
9. Peri-operative use of nonsteroidal anti-inflammatory drugs in children.
- Author
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Walmsley AJ
- Subjects
- Administration, Oral, Child, Humans, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Pain, Postoperative prevention & control
- Published
- 1997
10. Patient consent and rectal drug administration.
- Author
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Vyvyan HA
- Subjects
- Administration, Rectal, Humans, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Informed Consent
- Published
- 1996
- Full Text
- View/download PDF
11. Postoperative analgesia in dental day case surgery. A comparison between Feldene "Melt' (piroxicam) and diclofenac suppositories.
- Author
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Wakeling HG, Barry PC, and Butler PJ
- Subjects
- Administration, Oral, Double-Blind Method, Humans, Suppositories, Time Factors, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Diclofenac administration & dosage, Pain, Postoperative prevention & control, Piroxicam administration & dosage, Tooth Extraction
- Abstract
A randomised, double-blind placebo-controlled trial was conducted to compare the analgesic efficacy of piroxicam as Feldene "Melt' with diclofenac suppositories following day case wisdom tooth extraction. Piroxicam was found to be equivalent to diclofenac in speed of onset and efficacy when given 1 h prior to surgery with no significant adverse effects. It is therefore possible to confer the benefits of postoperative analgesia from a non-steroidal anti-inflammatory drug whilst avoiding the inconvenience of the rectal route of administration.
- Published
- 1996
- Full Text
- View/download PDF
12. Analgesia for day surgery. Evaluation of the effect of diclofenac given before or after surgery with or without bupivacaine infiltration.
- Author
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Chan A, Doré CJ, and Ramachandra V
- Subjects
- Adolescent, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Diclofenac therapeutic use, Double-Blind Method, Drug Administration Schedule, Female, Humans, Mastectomy, Segmental, Middle Aged, Pain Measurement, Ambulatory Surgical Procedures, Analgesia methods, Anesthetics, Local, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Bupivacaine, Diclofenac administration & dosage, Pain, Postoperative prevention & control
- Abstract
One hundred patients undergoing breast lump excision using a standard anaesthetic technique in the Day Care Unit were randomly divided into five groups. Groups A and B received either saline or diclofenac in a double-blind fashion before and at the end of the procedure, with both groups receiving 10 ml of 0.5% bupivacaine infiltration at the end. Groups C and D also received saline or diclofenac before and after surgery but had no bupivacaine infiltration at the end. Group E did not receive any injections but had bupivacaine infiltration at the end of surgery. In the postoperative period, pain was assessed by a visual analogue scale at 30 min intervals until discharge. All patients were requested to complete a pain relief questionnaire over the 48 h following surgery. There were highly significant differences between those who received bupivacaine and those who did not in the visual analogue scale scores at 30 min (p < 0.001), 60 min (p < 0.001), 120 min postoperatively (p = 0.02) and at discharge (p = 0.03). Pain scores were lower in those who received bupivacaine and they were less likely to request rescue medication, although this did not reach significance (p = 0.07). There were significant differences between the groups who received bupivacaine and diclofenac injection and those who received bupivacaine alone for visual analogue scale scores at 60 min following surgery (p = 0.05) and at 48 h (p = 0.002). Pain relief was better in those patients who received both bupivacaine and diclofenac injection. Although not significant (p = 0.22), fewer patients required rescue medication when diclofenac was given before surgery (10%) rather than after surgery (22.5%). Fewer patients had a fair amount or a great deal of pain in the 48 h following surgery when diclofenac was injected before (7.5%) rather than after surgery (12.5%). The mean number of oral analgesics taken in the 48 h after surgery was also lower in those patients who had the diclofenac before the surgery rather than after.
- Published
- 1996
- Full Text
- View/download PDF
13. Patients' attitudes to rectal drug administration.
- Author
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Vyvyan HA and Hanafiah Z
- Subjects
- Adolescent, Adult, Ambulatory Surgical Procedures, Diclofenac administration & dosage, Female, Humans, Informed Consent, Intraoperative Care, Male, Middle Aged, Suppositories, Surveys and Questionnaires, Administration, Rectal, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Attitude, Pain, Postoperative prevention & control
- Abstract
One hundred adult patients attending for day case surgery were surveyed by anonymous questionnaire in order to determine their attitudes to rectal drug administration. Fifty four patients did not want an analgesic drug (diclofenac sodium) administered rectally whilst under anaesthesia, all preferring to take it orally if available. Ninety eight patients thought that drugs administered per rectum should always be discussed with them beforehand and a few had very strong feelings about this route of administration. We suggest that prescribers of rectal diclofenac should always discuss it with patients pre-operatively. Whilst many are happy to have suppositories, some young patients are sensitive about this and prefer to take such medication by mouth.
- Published
- 1995
- Full Text
- View/download PDF
14. The effect of a combination of rectal diclofenac and caudal bupivacaine on postoperative analgesia in children.
- Author
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Gadiyar V, Gallagher TM, Crean PM, and Taylor RH
- Subjects
- Administration, Rectal, Child, Child, Preschool, Circumcision, Male, Cryptorchidism surgery, Double-Blind Method, Drug Therapy, Combination, Hernia, Inguinal surgery, Humans, Male, Anesthetics, Local administration & dosage, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Autonomic Nerve Block, Bupivacaine administration & dosage, Diclofenac administration & dosage, Pain, Postoperative drug therapy
- Abstract
Both caudal anaesthesia and non-steroidal anti-inflammatory drugs have been used in the management of postoperative pain in children. The aim of the present study was to evaluate the combination of caudal analgesia and rectally administered diclofenac in the treatment of pain following minor surgery in children. Thirty-nine, ASA grade 1 or 2, children undergoing inguinal or penoscrotal surgery were randomly assigned to receive either a caudal block using 0.125% bupivacaine with adrenaline or a similar caudal block in combination with rectally administered diclofenac 1 mg.kg-1. Children given a caudal block alone were more likely to need analgesia in the first 24 h postoperatively. It would appear that the combination of a caudal block and rectal diclofenac in children undergoing minor lower abdominal surgery reduces the need for subsequent analgesia.
- Published
- 1995
- Full Text
- View/download PDF
15. Analgesia after caesarean section. The use of rectal diclofenac as an adjunct to spinal morphine.
- Author
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Dennis AR, Leeson-Payne CG, and Hobbs GJ
- Subjects
- Adult, Diclofenac adverse effects, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Pregnancy, Prospective Studies, Suppositories, Analgesia, Obstetrical methods, Cesarean Section, Diclofenac administration & dosage, Morphine administration & dosage, Pain, Postoperative drug therapy
- Abstract
A double-blind placebo-controlled study was performed to assess the analgesic effect of rectal sodium diclofenac 100 mg after Caesarean section using subarachnoid hyperbaric bupivacaine 0.5% and morphine 0.2 mg. During the 48 h follow-up period, both placebo and diclofenac groups had comparable analgesia as measured by visual analogue scores (VAS) at rest and on movement. However, diclofenac prolonged the mean time to first analgesia by more than 5 h from 13 h 45 min in the placebo group to 18 h 58 min (p < 0.03). The incidence of side effects (nausea, vomiting, itching, excessive lochia loss and the need for additional analgesia) were comparable in each group.
- Published
- 1995
- Full Text
- View/download PDF
16. Postoperative pain relief in children. A comparison between caudal bupivacaine and intramuscular diclofenac sodium.
- Author
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Ryhänen P, Adamski J, Puhakka K, Leppäluoto J, Vuolteenaho O, and Ryhänen J
- Subjects
- Child, Child, Preschool, Cryptorchidism surgery, Diclofenac blood, Drug Administration Schedule, Female, Hernia, Inguinal surgery, Humans, Infant, Male, Meperidine administration & dosage, Testis surgery, Analgesia, Epidural, Bupivacaine administration & dosage, Diclofenac administration & dosage, Pain, Postoperative prevention & control, Premedication
- Abstract
Two hundred and fifty children undergoing herniotomy or orchidopexy under general anaesthesia were randomly allocated to receive pre-operatively either diclofenac sodium 1 mg.kg-1 given intramuscularly or a caudal injection of bupivacaine 0.25% 1 ml.kg-1 with or without adrenaline or no analgesia. Plasma diclofenac and beta-endorphin concentrations were determined in eight and 21 patients respectively. Postoperative pain was assessed by ward nurses who were blinded to the group allocation. Comparison with the control group showed diclofenac to be an effective analgesic. Caudal bupivacaine provided more pain-free children during the early postoperative hours, but later the need for pethidine as rescue analgesic was lower among the children who had received intramuscular diclofenac. Caudal analgesia abolished the stress-induced increase in plasma beta-endorphin level which was found in the children given diclofenac and in those who served as controls. Total plasma clearance of intramuscular diclofenac sodium appears to be higher in children than in adults. A single intramuscular dose of diclofenac significantly reduces the need for an opioid analgesic in children after inguinal herniotomy or orchidopexy, and owing to its long duration of action, it offers an alternative or complementary method of pain relief to caudal analgesia.
- Published
- 1994
- Full Text
- View/download PDF
17. The effect of paracetamol or diclofenac administered before operation on postoperative pain and behaviour after adenoidectomy in small children.
- Author
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Baer GA, Rorarius MG, Kolehmainen S, and Selin S
- Subjects
- Adenoidectomy, Administration, Rectal, Child Behavior drug effects, Child, Preschool, Crying, Humans, Infant, Psychomotor Agitation prevention & control, Acetaminophen administration & dosage, Diclofenac administration & dosage, Pain, Postoperative prevention & control, Premedication
- Abstract
We compared the effects of rectally administered diclofenac (12.5 mg) with paracetamol (125 mg) on pre- and postoperative behaviour and the need for supplementary analgesia in 44 children scheduled for adenoidectomy (with or without myringotomy). The study drugs were given in combination with diazepam (0.5 mg.kg-1) about 20 min before the children were taken to the operating theatre. On arrival there, the children who had received diclofenac were significantly quieter (< 0.05), easier to handle (p < 0.01) and cried less (p < 0.05) than those in the paracetamol group. During recovery, children in the diclofenac group needed fewer supplementary doses of intravenous pethidine than those receiving paracetamol (p < 0.001). There were no obvious differences between the groups in intra-operative bleeding (as estimated by the surgeon), or in measured blood loss. No postoperative complications became evident. The pre-operative rectal administration of diclofenac for pain relief after adenotomy is safe and effective.
- Published
- 1992
- Full Text
- View/download PDF
18. Platelet function after intramuscular diclofenac.
- Author
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Power I, Chambers WA, Greer IA, Ramage D, and Simon E
- Subjects
- Adult, Aged, Bleeding Time, Blood Platelets physiology, Diclofenac administration & dosage, Double-Blind Method, Female, Humans, Injections, Intramuscular, Intraoperative Period, Male, Middle Aged, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors pharmacology, Blood Platelets drug effects, Diclofenac pharmacology
- Abstract
A randomised double-blind controlled study was performed to examine the effect of diclofenac on skin bleeding time and in vitro whole blood platelet aggregation. Twenty thoracotomy patients were studied; 10 were given diclofenac 75 mg intramuscularly at induction of anaesthesia, and 10 formed a control group. Skin bleeding times and platelet aggregation tests were performed the day before and repeated one hour after induction of anaesthesia. Diclofenac prolonged skin bleeding time and reduced platelet aggregation. There were no significant changes in the control group.
- Published
- 1990
- Full Text
- View/download PDF
19. Intravenous diclofenac sodium. Does its administration before operation suppress postoperative pain?
- Author
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Campbell WI, Kendrick R, and Patterson C
- Subjects
- Adolescent, Adult, Aged, Diclofenac therapeutic use, Double-Blind Method, Female, Fentanyl therapeutic use, Humans, Injections, Intramuscular, Injections, Intravenous, Male, Middle Aged, Pain Measurement, Premedication, Time Factors, Tooth Extraction, Diclofenac administration & dosage, Pain, Postoperative prevention & control
- Abstract
Intravenous diclofenac sodium was evaluated in a double-blind randomised trial relative to intramuscular diclofenac, intravenous fentanyl, and intramuscular placebo in 160 patients undergoing extraction of impacted lower third molar teeth. The test drug was administered before operation in an attempt to alleviate postoperative pain. A 10-cm visual analogue scale was used to assess pain at 30 minutes and one day after surgery, if the patients stayed overnight. Patients who received intravenous diclofenac had significantly less pain than the other groups 30 minutes after operation. They also had significantly less pain one day after surgery than the placebo or opioid groups, but not less than the intramuscular diclofenac group. Capillary bleeding time, in comparison with placebo, was significantly prolonged after the use of intramuscular diclofenac, and a similar but nonsignificant trend was observed in the intravenous diclofenac group. No problems were encountered with excessive bleeding in any group.
- Published
- 1990
- Full Text
- View/download PDF
20. Postoperative nefopam and diclofenac. Evaluation of their morphine-sparing effect after upper abdominal surgery.
- Author
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Moffat AC, Kenny GN, and Prentice JW
- Subjects
- Adult, Aged, Diclofenac administration & dosage, Drug Evaluation, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Morphine administration & dosage, Morphine adverse effects, Nefopam administration & dosage, Nefopam adverse effects, Random Allocation, Abdomen surgery, Diclofenac therapeutic use, Nefopam therapeutic use, Oxazocines therapeutic use, Pain, Postoperative drug therapy
- Abstract
The aim of the study was to assess the relative morphine-sparing effects of nefopam and diclofenac when used singly or in combination after upper abdominal surgery. Eighty-four patients of ASA grade 1 or 2 were allocated randomly to one of three groups. Group A received nefopam 20 mg by intramuscular injection 6 hourly after surgery for the 24-hour study period. Group B received diclofenac 75 mg 12-hourly and placebo injections at 6 and 18 hours after surgery. Group C received both 6-hourly nefopam and 12-hourly diclofenac. Supplemental analgesia was given on demand via a patient-controlled analgesia system which delivered intravenous morphine. Morphine requirements in the diclofenac group were significantly lower than in either of the other groups (p less than 0.01). Patients who received the combination of nefopam and diclofenac required significantly less morphine than those who received nefopam alone (p less than 0.01). Pain scores assessed 6 hours after surgery were significantly lower in the diclofenac and combination groups compared with the nefopam group (p less than 0.01).
- Published
- 1990
- Full Text
- View/download PDF
21. Paediatric postoperative analgesia. A comparison of rectal diclofenac with caudal bupivacaine after inguinal herniotomy.
- Author
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Moores MA, Wandless JG, and Fell D
- Subjects
- Administration, Rectal, Ambulatory Surgical Procedures, Child, Child, Preschool, Diclofenac adverse effects, Diclofenac therapeutic use, Humans, Infant, Random Allocation, Anesthesia, Caudal adverse effects, Anesthesia, Epidural adverse effects, Bupivacaine adverse effects, Diclofenac administration & dosage, Hernia, Inguinal surgery, Pain, Postoperative prevention & control
- Abstract
Forty-three children for day case inguinal herniotomy under general anaesthesia were assigned randomly to receive either 1 ml/kg caudal bupivacaine 0.25% or rectal diclofenac 0.25 mg/kg intra-operatively to provide postoperative analgesia. Pain and demeanour were assessed by an observer in the early postoperative period after operation and by questionnaire for the parents over the first 24 hours. Caudal bupivacaine provided more pain-free patients at first but later the incidence of pain was similar in the two treatment groups. Rectal diclofenac is a useful alternative to caudal blockade in this group of patients.
- Published
- 1990
- Full Text
- View/download PDF
22. Failure of rectal diclofenac to augment opioid analgesia.
- Author
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Derbyshire DR
- Subjects
- Administration, Rectal, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Drug Synergism, Female, Genitalia, Female surgery, Humans, Analgesia methods, Diclofenac administration & dosage, Opium
- Published
- 1989
- Full Text
- View/download PDF
23. Failure of rectal diclofenac to augment opioid analgesia after cholecystectomy.
- Author
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Colquhoun AD and Fell D
- Subjects
- Administration, Rectal, Adolescent, Adult, Aged, Clinical Trials as Topic, Diclofenac administration & dosage, Double-Blind Method, Female, Humans, Male, Middle Aged, Morphine therapeutic use, Random Allocation, Suppositories, Cholecystectomy, Diclofenac therapeutic use, Pain, Postoperative drug therapy
- Abstract
The analgesic efficacy of a single 100-mg suppository of diclofenac sodium given after elective cholecystectomy was studied in 30 healthy patients in a double-blind randomised controlled manner. The mean 24-hour postoperative morphine consumption of the placebo group and the diclofenac group was similar (45 mg). Analysis of the cumulative hourly morphine consumption from the patient-controlled analgesia system failed to show any statistically significant differences between the groups. Peak expiratory flow rate, forced expiratory volume at 1 second and forced vital capacity decreased 24 hours after operation to less than 50% of pre-operative values in both groups. Subjective experiences of pain, nausea and drowsiness assessed by linear analogue scoring were similar in both groups.
- Published
- 1989
- Full Text
- View/download PDF
24. A comparison of rectal diclofenac with intramuscular papaveretum or placebo for pain relief following tonsillectomy.
- Author
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Bone ME and Fell D
- Subjects
- Administration, Rectal, Child, Diclofenac administration & dosage, Drug Evaluation, Female, Humans, Injections, Intramuscular, Male, Opium administration & dosage, Diclofenac therapeutic use, Opium therapeutic use, Pain, Postoperative drug therapy, Tonsillectomy
- Abstract
A controlled investigation was conducted to compare the effectiveness of diclofenac and papaveretum in the prevention of pain and restlessness after tonsillectomy in children. Sixty children between 3 and 13 years of age were randomly allocated to receive rectal diclofenac 2 mg/kg, intramuscular papaveretum 0.2 mg/kg or no medication immediately after induction of anaesthesia. Pain and appearance were assessed 1, 3 and 6 hours postoperatively, and the following morning. The assessments were double-blind and performed by the same observer. No significant differences in postoperative pain were found between the groups at any time. The use of diclofenac was associated with a significantly more rapid return to calm wakefulness and had significantly less effect upon respiratory rate. Consumption of paracetamol on the day of operation was significantly less in the diclofenac group. Diclofenac may offer advantages compared to papaveretum with regard to safety and convenience for use in the treatment of pain after tonsillectomy in children.
- Published
- 1988
- Full Text
- View/download PDF
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