1. Visualization of exhaled hydrogen sulphide on test paper with an ultrasensitive and time-gated luminescent probe.
- Author
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Zhang, Ruilong, Liu, Shijiang, Wang, Jianping, Han, Guangmei, Yang, Linlin, Liu, Bianhua, Guan, Guijian, and Zhang, Zhongping
- Subjects
CHEMORECEPTORS ,HYDROGEN sulfide ,AQUEOUS solutions ,PUBLIC health ,LUMINESCENT probes - Abstract
Luminescent chemosensors for hydrogen sulphide (H
2 S) are of great interest because of the close association of H2 S with our health. However, current probes for H2 S detection have problems such as low sensitivity/selectivity, poor aqueous-solubility or interference from background fluorescence. This study reports an ultrasensitive and time-gated “switch on” probe for detection of H2 S, and its application in test paper for visualization of exhaled H2 S. The complex probe is synthesized with a luminescent Tb3+ centre and three ligands of azido (–N3 ) substituted pyridine-2,6-dicarboxylic acid, giving the probe high hydrophilicity and relatively fast reaction dynamics with H2 S because there are three –N3 groups in each molecule. The introduced –N3 group as a strong electron-withdrawing moiety effectively changes the energy level of ligand via intramolecular charge transfer (ICT), and thus breaks the energy transferring from ligand to lanthanide ion, resulting in quenching of Tb3+ luminescence. On addition of H2 S, the –N3 group can be reduced to an amine group to break the process of ICT, and the luminescence of Tb3+ is recovered at a nanomolar sensitivity level. With a long lifetime of luminescence of Tb3+ centre (1.9 ms), use of a time-gated technique effectively eliminates the background fluorescence by delaying fluorescence collection for 0.1 ms. The test paper imprinted by the complex probe ink can visualize clearly the trace H2 S gas exhaled by mice. [ABSTRACT FROM AUTHOR]- Published
- 2016
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