1. Ultrasensitive detection of vitamin E by signal conversion combined with core-satellite structure-based plasmon coupling effect.
- Author
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Xu, Keying, Li, Jing, Han, Qingyi, Zhang, Dingding, Zhang, Libing, Zhang, Zhen, and Lu, Xiaoquan
- Subjects
VITAMIN E ,SERS spectroscopy ,NEUROMUSCULAR diseases ,EPITAXY ,GOLD nanoparticles ,ORGANIC conductors - Abstract
The rapid and sensitive surface-enhanced Raman scattering (SERS) detection of molecular biomarkers from real samples is still a challenge because the intrinsically trace analytes may have a low molecular affinity for metal surfaces. Herein, we develop a smart signal conversion and amplification strategy based on silver–gold–silica core-satellite structure nanoparticles (Ag@Au@SiO
2 NPs) to sensitively detect low adsorptive vitamin E using SERS, which has been considered a biomarker of neuromuscular disorders when its abnormal content is measured in the serum of patients. Through the reducibility of vitamin E, Ag+ ions are rapidly reduced to Ag atoms, resulting in the epitaxial growth of Ag nanocrystals on gold nanoparticles forming satellite particle–particle gap-narrowed Ag@Au@SiO2 NPs. The generated strong plasmonic field dramatically enhances the Raman signal of the Raman reporter molecule 4-aminothiophenol (4-ATP) and the detected vitamin E molecules at an estimated level of 58.19 nmol L−1 . The sensitivity of this operational SERS strategy provides tremendous prospects for the screening of neuromuscular disorders. [ABSTRACT FROM AUTHOR]- Published
- 2022
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