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Start Over Author "Kim Halbert" Journal analytica chimica acta
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1. Amperometric detection of thiopurines in blood plasma with a cobalt-phthalocyanine chemically modified electrode after liquid chromatography

Author

Richard P. Baldwin and Mary Kim Halbert

Subjects
Detection limit, Chromatography, chemistry.chemical_element, Biochemistry, Fluorescence, Amperometry, Analytical Chemistry, chemistry, Electrode, Blood plasma, Environmental Chemistry, Sample preparation, Cobalt, Spectroscopy, Chemically modified electrode
Abstract

Cobalt phthalocyanine-containing carbon paste electrodes are used as electrocatalytic amperometric sensors for 6-mercaptopurine, 6-thioguanine, and several related thiopurines in blood plasma after separation by liquid chromatography. Required sample preparation is minimal, and total quantitation time is 8 min or less. Detection limits are 1.5–8 pmol, approximately an order of magnitude better than that obtained with ultraviolet or fluorescence detection.

Published
1986

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