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Start Over Author "Ma, Hongmin" Journal analytica chimica acta
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20. Original signal amplification assay for N-Terminal pro-brain natriuretic peptide detection based on Bi 2 MoO 6 photosensitive matrix.

Author

Xu R, Li J, Liu L, Liu X, Fan D, Cao W, Ma H, and Wei Q

Subjects
Antibodies, Immobilized immunology, Cadmium chemistry, Electrochemical Techniques, Gold chemistry, Humans, Limit of Detection, Metal Nanoparticles chemistry, Natriuretic Peptide, Brain immunology, Peptide Fragments immunology, Reproducibility of Results, Zinc chemistry, Bismuth chemistry, Immunoassay methods, Molybdenum chemistry, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Surface Plasmon Resonance methods
Abstract

An original dual signal amplification immunoassay for N-Terminal pro-brain natriuretic peptide (NT-proBNP) detection is developed based on Au NPs and Zn doped CdS nanoparticles (Zn 0.02 Cd 0.98 S) co-sensitized Bi 2 MoO 6 nanosheet photoelectrochemical (PEC) platform, the target is a good myocardial marker for diagnosing heart failure (HF). Bi 2 MoO 6 as an outstanding photocatalysis material is successfully used in PEC analysis in this work, and the nanosheet structure provide a preponderance to capture superior Zn 0.02 Cd 0.98 S in order to achieve anticipant PEC response. The doping of Zn makes the energy band of CdS matched more compatible with Bi 2 MoO 6 , and improves the narrow band gap of CdS, making the surface plasma resonance (SPR) effect of Au NPs more significant, thus further improving the PEC response, as well as elevated the detection sensitivity of biological targets. The constructed PEC platform for NT-proBNP provides a wide detection range of 0.0001-1000 ng mL -1 and gives the minimum detection value of 0.037 pg mL -1 . Great stability, high selectivity, and good reproducibility are also achieved. The proposed PEC immunoassay provides more possibilities for other protein ultra-sensitivity detection., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2020
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