1. Modulating the Morphology of Gold Graphitic Nanocapsules for Plasmon Resonance-Enhanced Multimodal Imaging.
- Author
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Xiao-Fang Lai, Yu-Xiu Zou, Shan-Shan Wang, Meng-Jie Zheng, Xiao-Xiao Hu, Hao Liang, Yi-Ting Xu, Xue-Wei Wang, Ding Ding, Long Chen, Zhuo Chen, and Weihong Tan
- Subjects
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NANOCAPSULES , *SURFACE plasmon resonance , *RAMAN spectroscopy , *CHEMICAL vapor deposition , *APTAMERS - Abstract
With their unique optical properties and distinct Raman signatures, graphitic nanomaterials can serve as substrates for surface-enhanced Raman spectroscopy (SERS) or provide signal amplification for bioanalysis and detection. However, a relatively weak Raman signal has limited further biomedical applications. This has been addressed by encapsulating gold nanorods (AuNRs) in a thin graphitic shell to form gold graphitic nanocapsules. This step improves plasmon resonance, which enhances Raman intensity, and has the potential for integrating two-photon luminescence (TPL) imaging capability. However, changing the morphology of gold graphitic nanocapsules such that high quality and stability are achieved remains a challenge. To address this task, we herein report a confinement chemical vapor deposition (CVD) method to prepare the construction of AuNR-encapsulated graphitic nanocapsules with these properties. Specifically, through morphological modulation, we (1) achieved higher plasmon resonance with near-IR incident light, thus achieving greater Raman intensity, and (2) successfully integrated two-photon luminescence dual-modal (Raman/TPL) bioimaging capabilities. Cancer-cell-specific aptamers were further modified on the AuNR@G graphitic surface through simple, but strong, π-π interactions to achieve imaging selectivity through differential cancer cell recognition. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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