1. Electrochemical Determination of Citalopram by Adsorptive Stripping Voltammetry–Determination in Pharmaceutical Products.
- Author
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Nouws, HenriP. A., Delerue‐Matos, Cristina, and Barros, AquilesA.
- Subjects
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ELECTROCHEMICAL analysis , *VOLTAMMETRY , *PHARMACY , *DRUGS , *STANDARD deviations , *ELECTROLYTES - Abstract
The electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately - 1.25 V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0 × 10-7 and 2.0 × 10-6 molL-1 with a limit of detection of 5 × 10-8molL-1 for an accumulation time of 30s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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