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Your search keyword '"Nortriptyline Hydrochloride"' showing total 4 results
Start Over Descriptor "Nortriptyline Hydrochloride" Journal analytical letters
4 results on '"Nortriptyline Hydrochloride"'

1. Simultaneous Spectrophotometric Determination of Imipramine Hydrochloride with Chlordiazepoxide and Nortriptyline Hydrochloride with Fluphenazine Hydrochloride

Author

Erwin Adams, Nabawia M. El-Guindi, Samir M. El-Moghazy, Marwa F. Mansour, Ann Van Schepdael, and Ehab F. Elkady

Subjects
Chromatography, medicine.diagnostic_test, Chemistry, 010401 analytical chemistry, Biochemistry (medical), Clinical Biochemistry, Fluphenazine hydrochloride, Multivariate calibration, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Chlordiazepoxide, Chemometrics, Nortriptyline Hydrochloride, Spectrophotometry, Electrochemistry, medicine, 0210 nano-technology, Imipramine Hydrochloride, Spectroscopy, medicine.drug
Abstract

Spectrophotometry was used with multivariate calibration to simultaneously determine compounds in mixtures. Two antidepressant mixtures were investigated: imipramine hydrochloride and chlordiazepox...

Published
2017

2. SPECTROPHOTOMETRIC AND STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF NORTRIPTYLINE HYDROCHLORIDE AND FLUPHENAZINE HYDROCHLORIDE.

Author

El-Ragehy, Nariman A., Abbas, Samah S., and El-Khateeb, Sonia Z.

Subjects
*ANTIDEPRESSANTS, *ANTIPSYCHOTIC agents, *SPECTROPHOTOMETRY, *HIGH performance liquid chromatography
Abstract

Spectrophotometric and high performance liquid chromatographic procedures are described for determination of nortriptyline hydrochloride and fluphenazine hydrochloride. The first procedure is based on application of first derivative of ratio spectra (¹DD) for quantitative determination of nortriptyline hydrochloride in presence of fluphenazine hydrochloride. Secondly, an accurate, sensitive and stability indicating method has been introduced for determination of nortriptyline hydrochloride and fluphenazine hydrochloride in both bulk powder and in dosage form. In the derivative ratio method, Beer's law is obeyed in the concentration ranges of 8-32 µg mL[sup -1] and 4-32 µg mL[sup -1] of nortriptyline hydrochloride at wavelengths 271.4 and 284.2 nm, respectively. In high performance liquid chromatographic method, linear relationship in the range of 0.6-3.6 µg mL[sup -1] and 1.2-4.2 µg mL[sup -1] for nortriptyline hydrochloride and fluphenazine hydrochloride, respectively, was obtained. The mobile phase used was 0.05 M ammonium acetate: methanol: acetonitrile (4:1:5 v/v/v), and detection was done spectrophotometrically at 254 nm. Results were statistically analyzed and compared with those obtained by applying the British Pharmacopoeia (2000) method. [ABSTRACT FROM AUTHOR]

Published
2002
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3. SPECTROPHOTOMETRIC AND STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF NORTRIPTYLINE HYDROCHLORIDE AND FLUPHENAZINE HYDROCHLORIDE

Author

Nariman A. El-Ragehy, Samah S. Abbas, and S. Z. El-khateeb

Subjects
Fluphenazine, Chromatography, Chemistry, Biochemistry (medical), Clinical Biochemistry, Fluphenazine hydrochloride, Derivative, Biochemistry, High-performance liquid chromatography, Dosage form, Analytical Chemistry, Nortriptyline Hydrochloride, Electrochemistry, medicine, Nortriptyline, Quantitative analysis (chemistry), Spectroscopy, medicine.drug
Abstract

Spectrophotometric and high performance liquid chromatographic procedures are described for determination of nortriptyline hydrochloride and fluphenazine hydrochloride. The first procedure is based on application of first derivative of ratio spectra (1DD) for quantitative determination of nortriptyline hydrochloride in presence of fluphenazine hydrochloride. Secondly, an accurate, sensitive and stability indicating method has been introduced for determination of nortriptyline hydrochloride and fluphenazine hydrochloride in both bulk powder and in dosage form. In the derivative ratio method, Beer's law is obeyed in the concentration ranges of 8–32 µg mL−1 and 4–32 µg mL−1 of nortriptyline hydrochloride at wavelengths 271.4 and 284.2 nm, respectively. In high performance liquid chromatographic method, linear relationship in the range of 0.6–3.6 µg mL−1 and 1.2–4.2 µg mL−1 for nortriptyline hydrochloride and fluphenazine hydrochloride, respectively, was obtained. The mobile phase used was 0.05 M amm...

Published
2002

4. Spectrophotometric Assay of Fluphenazine HCL-Nortriptyline HCL Mixture in Tablets Using Fourier Function Method

Author

M. Abdel-Hady Elsayed, Hoda Mahgoub, Heba H. Abdine, and Mohamed A. Korany

Subjects
Fluphenazine, Chromatography, medicine.diagnostic_test, Chemistry, Biochemistry (medical), Clinical Biochemistry, Fluphenazine hydrochloride, Biochemistry, Dosage form, Analytical Chemistry, Absorbance, symbols.namesake, Fourier transform, Nortriptyline Hydrochloride, Spectrophotometry, Electrochemistry, medicine, symbols, Nortriptyline, Spectroscopy, medicine.drug
Abstract

The Fourier function method has been applied to the independent determination of fluphenazine hydrochloride (FH) and nortriptyline hydrochloride (KH) (1:20) in both laboratory made mixtures and commercial tablets. The method is based on the absorbance measurement of FE (the minor component) in concentrated mixture solutions, which is then properly diluted prior to NH absorbance measure

Published
1991

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