1. The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats.
- Author
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Yilmaz-Oral D, Onder A, Gur S, Carbonell-Barrachina ÁA, Kaya-Sezginer E, Oztekin CV, and Zor M
- Subjects
- Animals, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental metabolism, Erectile Dysfunction etiology, Erectile Dysfunction metabolism, Glyburide pharmacology, In Vitro Techniques, Injections, Male, Nifedipine pharmacology, Nitric Oxide Synthase antagonists & inhibitors, Oils, Volatile pharmacology, Penis drug effects, Potassium Channel Blockers pharmacology, Rats, Rats, Sprague-Dawley, Soluble Guanylyl Cyclase antagonists & inhibitors, Tetraethylammonium pharmacology, Clove Oil pharmacology, Diabetes Mellitus, Experimental physiopathology, Erectile Dysfunction physiopathology, Eugenol pharmacology, Penile Erection drug effects
- Abstract
Diabetic men are at a higher risk of erectile dysfunction (ED). A tropical plant, clove (Syn. Eugenia caryophyllata, Caryophyllus aromaticus L., Syzygium aromaticum (L.) Merr. & L.M. Perry) from the Myrtaceae family has displayed aphrodisiac activity. The present research aimed to investigate the impacts of clove essential oil (CEO) and the ingredient of CEO, eugenol (E) on ED in diabetic rats. We divided Sprague-Dawley rats into control and diabetic groups. Erectile function was evaluated before and after CEO and E intracavernosal injection. CEO- and E-induced relaxation responses were investigated in isolated corpus cavernosum (CC) using various inhibitors. The intracavernous administration of CEO and E restored erectile responses in diabetic rats. CEO and E induced remarkable relaxation in all groups. CEO- and E-induced relaxation responses were partially inhibited after pre-contraction with KCl. Tetraethylammonium and glibenclamide inhibited the relaxation response to CEO. Glibenclamide inhibited maximum relaxation to E. The inhibitors of nitric oxide synthase (NOS), soluble guanylyl cyclase and nifedipine did not change CEO- and E-induced relaxation responses. The current results suggest that CEO and the major compound of the essential oil, E improved diabetes-induced ED in rats, and CEO caused CC relaxation via K
+ channels independently NO signalling pathway., (© 2020 Blackwell Verlag GmbH.)- Published
- 2020
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