1. Sperm DNA integrity: a special issue exploring the causes, consequences, and treatment of DNA damage in human spermatozoa.
- Author
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Aitken, Robert John
- Subjects
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MALE infertility , *DNA damage , *SPERMATOZOA , *HUMAN DNA , *MALE reproductive organs , *DOUBLE-strand DNA breaks - Abstract
MANAGEMENT OF SPERM DNA DAMAGE In addition to the development of novel procedures for sperm isolation and recovery, we might also explore measures to better manage sperm DNA damage, in cases where the etiology is known. For example, if oxidative stress is centrally involved in the etiology of sperm DNA damage, we might ask what factors are involved in creating such stress to the point that both the genetic and epigenetic integrity of the spermatozoa are significantly compromised. Keywords: clinical; DNA damage; etiology; management; oxidative stress; spermatozoa EN clinical DNA damage etiology management oxidative stress spermatozoa 1541 1544 4 10/24/23 20231101 NES 231101 Since the pioneering studies by Don Evenson and colleagues first opened our eyes to the existence of DNA damage in subpopulations of human spermatozoa,[1] important questions have been raised concerning the causes, clinical significance, and resolution of this phenomenon.[2] In this Special Issue of Andrology, we have brought together a collection of cutting-edge research articles and reviews, reflecting the most recent advances in this area. [Extracted from the article]
- Published
- 2023
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