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We measured the effect of 5 and 10 cm H(2)O continuous positive airways pressure (CPAP) on middle cerebral artery blood flow velocity (FV) in 15 awake, healthy volunteers by using transcranial Doppler ultrasonography. Mean, systolic, and diastolic FV plus pulsatility index were recorded. No significant change in any measured variable was observed with the application of 5 or 10 cm H(2)O CPAP. These results are in contrast to those of a previous study, which found a significant increase in mean FV and a decrease in pulsatility index during the application of 12 cm H(2)O CPAP.