1. Neuromuscular Blockade Monitoring in Acute Respiratory Distress Syndrome: Randomized Controlled Trial of Clinical Assessment Alone or With Peripheral Nerve Stimulation
- Author
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Catherine Pilorge, Céline Sarfati, François Stéphan, Thibaut Genty, Audrey Imbert, Priscilla Amaru, Florent Laverdure, and Saida Rezaiguia-Delclaux
- Subjects
Adult ,Male ,ARDS ,Paris ,Time Factors ,medicine.medical_treatment ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,030202 anesthesiology ,law ,Predictive Value of Tests ,Medicine ,Humans ,Peripheral Nerves ,Prospective Studies ,Respiratory system ,Aged ,Mechanical ventilation ,Neuromuscular Blockade ,Respiratory Distress Syndrome ,business.industry ,Middle Aged ,medicine.disease ,Intensive care unit ,Respiration, Artificial ,Confidence interval ,Electric Stimulation ,Anesthesiology and Pain Medicine ,Treatment Outcome ,Anesthesia ,Breathing ,Atracurium ,Female ,Neuromuscular Monitoring ,business ,Ventilator Weaning ,030217 neurology & neurosurgery ,Neuromuscular Nondepolarizing Agents - Abstract
BACKGROUND Whether train-of-four (TOF) monitoring is more effective than clinical monitoring to guide neuromuscular blockade (NMB) in patients with acute respiratory distress syndrome (ARDS) is unclear. We compared clinical monitoring alone or with TOF monitoring to guide atracurium dosage adjustment with respect to drug dose and respiratory parameters. METHODS From 2015 to 2016, we conducted a randomized controlled trial comparing clinical assessments every 2 hours with or without corrugator supercilii TOF monitoring every 4 hours in patients who developed ARDS (Pao2/Fio2
- Published
- 2020