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Staphylococcus aureus (S. aureus) is able to hide within host cells to escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design of an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT (Cip‐CBT‐Ada), we propose a strategy of tandem guest‐host‐receptor recognitions to precisely guide ciprofloxacin to eliminate intracellular S. aureus. Via guest‐host recognition, Cip‐CBT‐Ada is decorated with a β‐cyclodextrin‐heptamannoside (CD‐M) derivative to yield Cip‐CBT‐Ada/CD‐M, which is able to target mannose receptor‐overexpressing macrophages via multivalent ligand‐receptor recognition. After uptake, Cip‐CBT‐Ada/CD‐M undergoes caspase‐1 (an overexpressed enzyme during S. aureus infection)‐initiated CBT‐Cys click reaction to self‐assemble into ciprofloxacin nanoparticle Nano‐Cip. In vitro and in vivo experiments demonstrate that, compared with ciprofloxacin or Cip‐CBT‐Ada, Cip‐CBT‐Ada/CD‐M shows superior intracellular bacteria elimination and inflammation alleviation efficiency in S. aureus‐infected RAW264.7 cells and mouse infection models, respectively. This work provides a supramolecular platform of tandem guest‐host‐receptor recognitions to precisely guide antibiotics to eliminate intracellular S. aureus infection efficiently. [ABSTRACT FROM AUTHOR]

To ensure sustainable hydrogen production by water electrolysis, robust, earth‐abundant, and high‐efficient electrocatalysts are required. Constructing a hybrid system could lead to further improvement in electrocatalytic activity. Interface engineering in composite catalysts is thus critical to determine the performance, and the phase‐junction interface should improve the catalytic activity. Here, we show that nickel diphosphide phase junction (c‐NiP2/m‐NiP2) is an effective electrocatalyst for hydrogen production in alkaline media. The overpotential (at 10 mA cm−2) for NiP2‐650 (c/m) in alkaline media could be significantly reduced by 26 % and 96 % compared with c‐NiP2 and m‐NiP2, respectively. The enhancement of catalytic activity should be attributed to the strong water dissociation ability and the rearrangement of electrons around the phase junction, which markedly improved the Volmer step and benefited the reduction process of adsorbed protons. [ABSTRACT FROM AUTHOR]

Oxygen vacancies are usually considered to be beneficial in catalytic conversion of polysulfides in lithium–sulfur batteries. Now it is demonstrated that the conversion of polysulfides was hindered by oxygen vacancies on ultrathin niobic acid. The inferior performance induced by the oxygen vacancy was mainly attributed to the decreased electric conductivity as well as the weakened adsorption of polysulfides on the catalyst surface. This work shows that the care should be taken when designing a new catalyst for the lithium–sulfur battery using a defect‐engineering strategy. [ABSTRACT FROM AUTHOR]

Frontispiz: Phase-Junction Electrocatalysts towards Enhanced Hydrogen Evolution Reaction in Alkaline Media Keywords: alkaline electrolytes; electrocatalysis; hydrogen evolution reaction; phase junctions EN alkaline electrolytes electrocatalysis hydrogen evolution reaction phase junctions 1 1 1 12/24/20 20210104 NES 210104 B Elektrokatalyse b Elektrokatalysatoren mit Phasenkontakt für die verstärkte Wasserstoffentwicklungsreaktion in alkalischen Medien werden von Bo Song et al. im Forschungsartikel auf S. 263 vorgestellt. Alkaline electrolytes, electrocatalysis, hydrogen evolution reaction, phase junctions. [Extracted from the article]

Highlights from the article: Wie B. Huang, Y. Du et al. in ihrem Forschungsartikel auf S. 11615 zeigen, beeinträchtigen Sauerstoff-Fehlstellen die Leistung hauptsächlich dadurch, dass sie die Leitfähigkeit verringern und die Adsorption von Polysulfid auf der Katalysatoroberfläche vermindern. Wie B. Huang, Y. Du et al. in ihrem Forschungsartikel auf S. 11615 zeigen, beeinträchtigen Sauerstoff-Fehlstellen die Leistung hauptsächlich dadurch, dass sie die Leitfähigkeit verringern und die Adsorption von Polysulfid auf der Katalysatoroberfläche vermindern. In ihrer Zuschrift auf S. 11551 beschreiben H. Grützmacher, J. E. Borger et al. die Synthese von Derivaten von Cyanophosphid [PCN] SP 2- sp .