1. Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System.
- Author
-
Xin, Pengyang, Xu, Linqi, Dong, Wenpei, Mao, Linlin, Guo, Jingjing, Bi, Jingjing, Zhang, Shouwei, Pei, Yan, and Chen, Chang‐Po
- Subjects
- *
POTASSIUM channels , *CELL membranes , *SUPRAMOLECULAR chemistry , *PERMEABILITY , *RUBIDIUM , *ALKALI metals , *ION channels - Abstract
Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF