1. Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry.
- Author
-
Nowak, Piotr, Saggiomo, Vittorio, Salehian, Fatemeh, Colomb-Delsuc, Mathieu, Han, Yang, and Otto, Sijbren
- Subjects
PHYSIOLOGICAL effects of nanoparticles ,GOLD nanoparticle synthesis ,LOCALIZED modes ,COMBINATORIAL chemistry ,IMINE synthesis ,CHEMICAL templates - Abstract
We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF