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Your search keyword '"Castro, Alberto"' showing total 4 results
Start Over Author "Castro, Alberto" Journal angewandte chemie
4 results on '"Castro, Alberto"'

2. Total Synthesis of Dragocins A−C through Electrochemical Cyclization.

Author

Smith, Brendyn P., Truax, Nathanyal J., Pollatos, Alexandros S., Meanwell, Michael, Bedekar, Pranali, Garrido‐Castro, Alberto F., and Baran, Phil S.

Subjects
RING formation (Chemistry), NATURAL products, RIBOSE, PYRROLIDINE, OXIDATION, MOLECULES
Abstract

The first total synthesis of dragocins A−C, remarkable natural products containing an unusual C4' oxidized ribose architecture bridged by a polyhydroxylated pyrrolidine, is presented through a route featuring a number of uncommon maneuvers. Several generations towards the target molecules are presented, including the spectacular failure of a key C−H oxidation on a late‐stage intermediate. The final route features rapid, stereocontrolled access to a densely functionalized pyrrolidine and an unprecedented diastereoselective oxidative electrochemical cyclization to forge the hallmark 9‐membered ring. Preliminary studies suggest this electrochemical oxidation protocol is generally useful. [ABSTRACT FROM AUTHOR]

Published
2024
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4. A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling

Author

Ni, Shengyang, primary, Garrido-Castro, Alberto F., additional, Merchant, Rohan R., additional, de Gruyter, Justine N., additional, Schmitt, Daniel C., additional, Mousseau, James J., additional, Gallego, Gary M., additional, Yang, Shouliang, additional, Collins, Michael R., additional, Qiao, Jennifer X., additional, Yeung, Kap-Sun, additional, Langley, David R., additional, Poss, Michael A., additional, Scola, Paul M., additional, Qin, Tian, additional, and Baran, Phil S., additional

Published
2018
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