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Start Over Author "Hammer, Stephan C." Journal angewandte chemie
11 results on '"Hammer, Stephan C."'

8. Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes.

Author

Demming, Rebecca M., Hammer, Stephan C., Nestl, Bettina M., Gergel, Sebastian, Fademrecht, Silvia, Pleiss, Jürgen, and Hauer, Bernhard

Subjects
*HYDRATION, *ALKENES, *SUBSTRATE integrated waveguides, *HYDROCARBONS, *ENANTIOSELECTIVE catalysis
Abstract

The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long‐standing challenge in catalysis. Here we report that an engineered fatty acid hydratase can catalyze the asymmetric hydration of various terminal and internal alkenes. In the presence of a carboxylic acid decoy molecule for activation of the oleate hydratase from E. meningoseptica, asymmetric hydration of unactivated alkenes was achieved with up to 93 % conversion, excellent selectivity (>99 % ee, >95 % regioselectivity), and on a preparative scale. [ABSTRACT FROM AUTHOR]

Published
2019
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9. Titelbild: Methylierung nicht‐aktivierter Alkene mit modifizierten Methyltransferasen zur Diversifizierung von Terpenoiden (Angew. Chem. 26/2023).

Author

Aberle, Benjamin, Kowalczyk, Daniel, Massini, Simon, Egler‐Kemmerer, Alexander‐N., Gergel, Sebastian, Hammer, Stephan C., and Hauer, Bernhard

Subjects
AMINO acid sequence, LAYERED double hydroxides, GREEN algae, ALKENES, ELECTRIC fields
Abstract

A variant with three changes in the amino acid sequence was able to produce methylated derivatives of linear terpenoids with high selectivity by C-methylation of an unactivated alkene. A variant with three changes in the amino acid sequence was able to produce methylated derivatives of linear terpenoids with high selectivity by C-methylation of an unactivated alkene. Keywords: Alken-Methylierung; Biokatalyse; Diversifizierung; Methyltransferase; Terpenoide DE Alken-Methylierung Biokatalyse Diversifizierung Methyltransferase Terpenoide 1 1 1 06/20/23 20230626 NES 230626 B A methyltransferase b from the green alga I Chlamydomonas reinhardtii i was identified and engineered for late-stage modifications of the carbon skeleton of terpenes. [Extracted from the article]

Published
2023
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