1. Scalable Rhodium(III)‐Catalyzed Aryl C−H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination.
- Author
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Wu, Zheng‐Jian, Su, Feng, Lin, Weidong, Song, Jinshuai, Wen, Ting‐Bin, Zhang, Hui‐Jun, and Xu, Hai‐Chao
- Subjects
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ANODIC oxidation of metals , *RHODIUM , *TRANSITION metals , *SILVER salts , *PHOSPHORYLATION , *OXIDIZING agents - Abstract
Transition metal catalyzed C−H phosphorylation remains an unsolved challenge. Reported methods are generally limited in scope and require stoichiometric silver salts as oxidants. Reported here is an electrochemically driven RhIII‐catalyzed aryl C−H phosphorylation reaction that proceeds through H2 evolution, obviating the need for stoichiometric metal oxidants. The method is compatible with a variety of aryl C−H and P−H coupling partners and particularly useful for synthesizing triarylphosphine oxides from diarylphosphine oxides, which are often difficult coupling partners for transition metal catalyzed C−H phosphorylation reactions. Experimental results suggest that the mechanism responsible for the C−P bond formation involves an oxidation‐induced reductive elimination process. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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