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Your search keyword '"Schmelz S"' showing total 2 results
Start Over Author "Schmelz S" Journal angewandte chemie international ed in english
2 results on '"Schmelz S"'

1. Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation.

Author

Siegmund V, Schmelz S, Dickgiesser S, Beck J, Ebenig A, Fittler H, Frauendorf H, Piater B, Betz UA, Avrutina O, Scrima A, Fuchsbauer HL, and Kolmar H

Subjects
Animals, CHO Cells, Cell Line, Tumor, Cetuximab metabolism, Cricetulus, Disulfides chemistry, Disulfides metabolism, Humans, Models, Molecular, Protein Conformation, Transglutaminases metabolism, Cetuximab chemistry, Transglutaminases chemistry
Abstract

Based on the crystal structure of a natural protein substrate for microbial transglutaminase, an enzyme that catalyzes protein crosslinking, a recognition motif for site-specific conjugation was rationally designed. Conformationally locked by an intramolecular disulfide bond, this structural mimic of a native conjugation site ensured efficient conjugation of a reporter cargo to the therapeutic monoclonal antibody cetuximab without erosion of its binding properties., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2015
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2. Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations.

Author

Tischler M, Nasu D, Empting M, Schmelz S, Heinz DW, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, and Avrutina O

Subjects
Amides pharmacology, Models, Molecular, Protease Inhibitors pharmacology, Structure-Activity Relationship, Amides chemistry, Biomimetic Materials chemistry, Peptides chemistry, Protease Inhibitors chemistry
Published
2012
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