1. Insights into Cytochrome P450 Enzyme Catalyzed Defluorination of Aromatic Fluorides.
- Author
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Zhang, Yi, Mokkawes, Thirakorn, and de Visser, Sam P.
- Subjects
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CYTOCHROME P-450 , *OXYGENASES , *SCISSION (Chemistry) , *REACTION mechanisms (Chemistry) , *ATOM transfer reactions , *ABSTRACTION reactions , *INORGANIC chemistry , *CYTOCHROME c - Abstract
This article discusses a study on the mechanism of aromatic defluorination by cytochrome P450 enzymes. The study used density functional calculations to explore the process and found that defluorination can occur through an initial epoxide intermediate or a 1,2-fluorine shift in an electrophilic intermediate. The research highlights the potential of P450 enzymes for oxidative defluorination reactions, which could have applications in biotechnology. The article also provides background information on the use of fluorinated compounds in various industries and the environmental concerns associated with their poor biodegradability. [Extracted from the article]
- Published
- 2023
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