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Start Over Author "Liu, Pengyun" Search Limiters Peer Reviewed Journal angewandte chemie international edition
2 results on '"Liu, Pengyun"'

2. Pd‐Catalyzed Asymmetric 5‐exo‐trig Cyclization/Cyclopropanation/Carbonylation of 1,6‐Enynes for the Construction of Chiral 3‐Azabicyclo[3.1.0]hexanes.

Author

Li, Qiuyu, Zhang, Yunchu, Liu, Pengyun, Zhong, Jing, Gong, Baihui, Yao, Hequan, and Lin, Aijun

Subjects
CYCLOPROPANATION, CARBONYLATION, RING formation (Chemistry), NUCLEOPHILES, HEXANE
Abstract

We herein disclose a mild and efficient access to chiral 3‐azabicyclo[3.1.0]hexanes via a Pd‐catalyzed asymmetric 5‐exo‐trig cyclization/cyclopropanation/carbonylation of 1,6‐enynes. Various nucleophiles, such as alcohols, phenols, amines and water, are well compatible with the reaction system. This reaction forms three C−C bonds, two rings, two adjacent quaternary carbon stereocenters as well as one C−O/C−N bond with excellent regio‐ and enantioselectivities. The products could be further functionalized to generate a library of 3‐azabicyclo[3.1.0]hexane frameworks. [ABSTRACT FROM AUTHOR]

Published
2023
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