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Your search keyword '"Castet, Frédéric"' showing total 1 results
Start Over Author "Castet, Frédéric" Topic alkynes Journal angewandte chemie international edition
1 results on '"Castet, Frédéric"'

1. Asymmetric Allenylation of Alkynes mediated by Chiral Organoselenated Reagents under Oxidative Conditions.

Author

Sun, Rongyu, Viaud, Emilie, Nomula, Rajesh, Naubron, Jean‐Valère, Daugey, Nicolas, Buffeteau, Thierry, Castet, Frédéric, Toullec, Patrick Y., Quideau, Stéphane, and Peixoto, Philippe A.

Subjects
ALKYNES, ASYMMETRIC synthesis
Abstract

The reactivity of novel chiral lactamide‐substituted diselenide‐based reagents under oxidative conditions was exploited to develop a metal‐free method for the preparation of enantioenriched allenylamides from simple alkynes in good yields, and with enantiomeric excesses up to 99 %. The key of the success in this method is attributed to the hydrogen‐bonded lactamide appendages that ensure configurational stability of chiral vinyl selenoxide intermediates for an optimal enantiotopic β‐syn‐elimination step. [ABSTRACT FROM AUTHOR]

Published
2023
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