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Your search keyword '"Akiyama, Takahiko"' showing total 1 results
Start Over Author "Akiyama, Takahiko" Topic carbonyl compounds Journal angewandte chemie international edition

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1 results on '"Akiyama, Takahiko"'

1. Chiral Copper(II) Phosphate Catalyzed Enantioselective Synthesis of Isochromene Derivatives by Sequential Intramolecular Cyclization and Asymmetric Transfer Hydrogenation of o-Alkynylacetophenones.

Author

Saito, Kodai, Kajiwara, Yuki, and Akiyama, Takahiko

Subjects
*ENANTIOSELECTIVE catalysis, *PHOSPHATES, *HYDROGENATION, *COPPER, *YLIDES, *CARBONYL compounds
Abstract

A good mix: The title reaction of o‐alkynylacetophenones with the Hantzsch ester in the presence of a chiral copper/phosphate catalyst proceeds in good yields with excellent enantioselectivities. The key intermediate for enantiocontrol is the ion pair of the carbonyl ylide with a chiral phosphate anion, and this process provides straight forward access to highly enantioriched chiral isochromenes. [ABSTRACT FROM AUTHOR]

Published
2013
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