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A semiconductor/environment interface has been formed in which suspended silicon nanowires (SiNWs) are in direct contact with photoactive TiO2 quantum dots. The photoactivity of TiO2 competes with the intrinsic photoresponses of p‐type silicon nanowires. Rational control of the competitive mechanism realizes remarkable mirror‐imaging photo‐switching and superior rectifying effects in a single SiNW‐based device. [ABSTRACT FROM AUTHOR]

Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of influenza H1N1 viruses with single‐molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit‐based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point‐of‐care clinical diagnosis.A bioassay design involving lithographically integrating point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of H1N1 viruses with single‐molecule sensitivity and high selectivity by using Si nanowires as local reporters in combination with microfluidics. This architecture is complementary to conventional optical techniques but has the advantages of no bleaching or fluorescent labeling. [ABSTRACT FROM AUTHOR]

Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real-time, label-free biodetection of influenza H1N1 viruses with single-molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit-based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point-of-care clinical diagnosis. [ABSTRACT FROM AUTHOR]

The front cover design of the international edition of volume 53, number 20, 2014 issue of the journal "Angewandte Chemie" is presented.