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Your search keyword '"Xu, Shu"' showing total 2 results
Start Over Author "Xu, Shu" Topic total synthesis Journal angewandte chemie international edition
2 results on '"Xu, Shu"'

1. Asymmetric Total Synthesis of Naphthospironone A.

Author

Liu, Jia‐Xuan, Zhang, Shi‐Peng, Sun, Feng‐Sen, Li, Hui, Gong, Ya‐Ling, Lu, Shi‐Chao, and Xu, Shu

Subjects
ASYMMETRIC synthesis, NATURAL products, RING formation (Chemistry)
Abstract

Naphthospironone A, a polyhydroxy cagelike bioactive natural product, was synthesised for the first time in this study. The spiro[bicyclo[3.2.1]octane‐pyran] core was constructed by an acid‐promoted epoxide‐opening lactonisation and a base‐induced intramolecular aldol‐type cyclisation. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Total Synthesis of the Antibiotic Kendomycin: A Macrocyclization Using the Tsuji-Trost Etherification.

Author

Sengoku, Tetsuya, Xu, Shu, Ogura, Kenji, Emori, Yoshinori, Kitada, Kenji, Uemura, Daisuke, and Arimoto, Hirokazu

Subjects
*ETHERIFICATION, *CONVERGENT evolution, *RING formation (Chemistry), *CHEMICAL reactions, *BENZYLIC group
Abstract

A highly stereocontrolled, convergent total synthesis of kendomycin [(−)-TAN2162], an ansa-macrocyclic antibiotic, is reported. The key of the strategy is an unprecedented Tsuji-Trost macrocyclic etherification, followed by a transannular Claisen rearrangement to construct the 18-membered carbocyclic framework. The oxa-six- and five-membered rings were also stereoselectively constructed respectively by a cascade oxidative cyclization at an unfunctionalized benzylic position and using a one-pot epoxidation/5- exo-tet epoxide opening. [ABSTRACT FROM AUTHOR]

Published
2014
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