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Start Over Author "Han Zuilhof" Journal angewandte chemie international edition
7 results on '"Han Zuilhof"'

2. Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices

Author

Roland A. Fischer, Anna Lisa Semrau, Philip M. Stanley, Bauke Albada, Mirza Cokoja, Han Zuilhof, Dominik Huber, and Michael Schuster

Subjects
Microchannel, Materials science, Organic Chemistry, Microfluidic devices, Microfluidics, Nanotechnology, General Chemistry, Metal-organic frameworks, Organische Chemie, Catalysis, Surface anchoring, Vectorial catalysis, Cascade reaction, Biocatalysis, Cascade, Metal-organic framework, Microscale chemistry, VLAG
Abstract

Vectorial Catalysis - controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device - is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal-organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalysts immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF = ~10 5 h -1 ).

Published
2021

3. Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)

Author

Jorge Escorihuela, Floris L. van Delft, Han Zuilhof, and Rickdeb Sen

Subjects
Kinetics, 02 engineering and technology, Metal-free click chemistry, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Catalysis, Química de superfícies, VLAG, Strain (chemistry), Bicyclic molecule, Chemistry, Communication, Organic Chemistry, General Medicine, General Chemistry, Cyclooctynes, 021001 nanoscience & nanotechnology, Organische Chemie, Surface chemistry, Combinatorial chemistry, Communications, Cycloaddition, 0104 chemical sciences, Quinone, Surface modification, 0210 nano-technology, Química orgànica
Abstract

Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non‐4‐yne (BCN) and surface‐bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART‐MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.

Published
2017

6. Inside Cover: A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit (Angew. Chem. Int. Ed. 32/2014)

Author

W. Bruce Turnbull, Thomas R. Branson, Stuart L. Warriner, Jaime Garcia-Hartjes, Tom E. McAllister, Martin A. Fascione, Tom Wennekes, James F. Ross, and Han Zuilhof

Subjects
chemistry.chemical_classification, Cholera Toxin B Subunit, Protein structure, Biochemistry, Chemistry, Stereochemistry, INT, A protein, Cover (algebra), General Chemistry, Glycoprotein, Catalysis
Published
2014

7. Covalently Attached Monolayers on Hydrogen-Terminated Si(100): Extremely Mild Attachment by Visible Light ( We thank the research school VLAG, the Netherlands Technology Foundation STW and the Human Frontier Science Program for financial support, and Cees Heijboer and Dr. Richard White (Thermo), and Dr. Klaus Simon (ASML) for stimulating discussions. Finally, we are thankful to a referee for constructive suggestions towards improvements of the manuscript. )

Author

Qiao-Yu Sun, Louis C. P. M. de Smet, Barend van Lagen, Andrew Wright, Han Zuilhof, and Ernst J. R. Sudhölter

Published
2004
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