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An asymmetric method for the synthesis of dihydropyrido[1,2- a]indoles from mixtures of nitrones and allenoates has been developed. This transformation showcases the use of squaramide catalysis in a complicated cascade system that has been shown to be highly sensitive to reaction conditions and substituent effects. The new method provides access to enantiomerically enriched dihydropyridoindoles from modular, non-indole reagents. The optimization and scope of the new transformation is discussed in addition to initial mechanistic experiments that indicate the role of the catalyst. [ABSTRACT FROM AUTHOR]

Please pass the oxygen: A new method for the preparation of trans‐α,β‐epoxyketimines has been achieved through a copper‐catalyzed rearrangement of (E)‐α,β‐unsaturated nitrones. The scope and tolerance of the method is evaluated and the synthetic utility of the products is demonstrated. The new transformation provides facile access to an unusual, densely functionalized intermediate that can be exploited for further synthetic application. [ABSTRACT FROM AUTHOR]