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Start Over Author "Serena Cuboni" Journal angewandte chemie international edition
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1. Snapshot of Antidepressants at Work: The Structure of Neurotransmitter Transporter Proteins

Author

Serena Cuboni and Felix Hausch

Subjects
Neurotransmitter transporter, biology, Chemistry, food and beverages, Drug design, Transporter, General Chemistry, Computational biology, biology.organism_classification, Catalysis, Membrane protein, Biochemistry, biology.protein, Antidepressant, Drosophila melanogaster, Reuptake inhibitor, Dopamine transporter
Abstract

In the sweet spot: Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.

Published
2014
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