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Your search keyword '"Unciti ‐ Broceta, Asier"' showing total 4 results
Start Over Author "Unciti ‐ Broceta, Asier" Journal angewandte chemie international edition
4 results on '"Unciti ‐ Broceta, Asier"'

2. Truly‐Biocompatible Gold Catalysis Enables Vivo‐Orthogonal Intra‐CNS Release of Anxiolytics.

Author

Ortega‐Liebana, M. Carmen, Porter, Nicola J., Adam, Catherine, Valero, Teresa, Hamilton, Lloyd, Sieger, Dirk, Becker, Catherina G., and Unciti‐Broceta, Asier

Subjects
TRANQUILIZING drugs, CATALYSIS, GOLD, CENTRAL nervous system, CENTRAL nervous system stimulants
Abstract

Being recognized as the best‐tolerated of all metals, the catalytic potential of gold (Au) has thus far been hindered by the ubiquitous presence of thiols in organisms. Herein we report the development of a truly‐catalytic Au‐polymer composite by assembling ultrasmall Au‐nanoparticles at the protein‐repelling outer layer of a co‐polymer scaffold via electrostatic loading. Illustrating the in vivo‐compatibility of the novel catalysts, we show their capacity to uncage the anxiolytic agent fluoxetine at the central nervous system (CNS) of developing zebrafish, influencing their swim pattern. This bioorthogonal strategy has enabled ‐for the first time‐ modification of cognitive activity by releasing a neuroactive agent directly in the brain of an animal. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Inside Back Cover: Gold‐Triggered Uncaging Chemistry in Living Systems (Angew. Chem. Int. Ed. 41/2017)

Author

Pérez‐López, Ana M., primary, Rubio‐Ruiz, Belén, additional, Sebastián, Víctor, additional, Hamilton, Lloyd, additional, Adam, Catherine, additional, Bray, Thomas L., additional, Irusta, Silvia, additional, Brennan, Paul M., additional, Lloyd‐Jones, Guy C., additional, Sieger, Dirk, additional, Santamaría, Jesús, additional, and Unciti‐Broceta, Asier, additional

Published
2017
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4. Gold‐Triggered Uncaging Chemistry in Living Systems

Author

Pérez‐López, Ana M., primary, Rubio‐Ruiz, Belén, additional, Sebastián, Víctor, additional, Hamilton, Lloyd, additional, Adam, Catherine, additional, Bray, Thomas L., additional, Irusta, Silvia, additional, Brennan, Paul M., additional, Lloyd‐Jones, Guy C., additional, Sieger, Dirk, additional, Santamaría, Jesús, additional, and Unciti‐Broceta, Asier, additional

Published
2017
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