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Start Over Descriptor "methylenecyclobutanes" Journal angewandte chemie international edition
1 results on '"methylenecyclobutanes"'

1. Highly Diastereoselective Synthesis of Methylenecyclobutanes by Merging Boron-Homologation and Boron-Allylation Strategies.

Author

Eisold, Michael and Didier, Dorian

Subjects
*CYCLOBUTANE synthesis, *ALLYLATION, *STEREOSELECTIVE reactions, *GOLD catalysts, *BENZALDEHYDE
Abstract

A highly diastereoselective synthesis of methylene-cyclobutanes possessing a quaternary stereocenter is reported, in which boron homologation of an easily-generated cyclobutenylmetal species is performed, followed by an allylation reaction. Combining three steps in a one-pot process further optimized the method, which afforded the expected adducts in excellent yields and stereoselectivity, starting from commercially available 4-bromobutyne. [ABSTRACT FROM AUTHOR]

Published
2015
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