1. Predictive Value of the Ankle-Brachial Index for All-Cause and Cardio-Cerebrovascular Mortality.
- Author
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Xu, Chang, Tian, Qi, Yu, Hao, Ge, Wei, Zheng, Huifen, and Huang, Danqing
- Subjects
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CAUSES of death , *PREDICTIVE tests , *ANKLE brachial index , *CEREBROVASCULAR disease , *REGRESSION analysis , *RISK assessment , *COMPARATIVE studies , *QUESTIONNAIRES , *KAPLAN-Meier estimator , *SOCIODEMOGRAPHIC factors , *PROPORTIONAL hazards models ,CARDIOVASCULAR disease related mortality - Abstract
The present study explored the relationship between the ankle-brachial index (ABI) (>.9) and all-cause or cardio-cerebrovascular mortality. Participant details were obtained from the National Health and Nutrition Examination Survey 1999–2004. The association between baseline ABI and the risk of mortality was evaluated by a priori defined quartile categories and on a continuous scale (per.1-unit change) with Cox regression models adjusted for demographic and traditional risk factors. A total of 7087 individuals (age: 59.6 ± 12.8 years) were included; 3612 (51.0%) were male. After an average follow-up of 12.2 years, 1926 deaths occurred. Kaplan–Meier analysis showed that the lowest ABI quartile (<1.06) was associated with the highest risk of all-cause, cardio-cerebrovascular and cancer mortality (all P <.001). However, after adjusting for potential confounders, ABI ranging between 1.06 and 1.12 was associated with the lowest risk of all-cause mortality (hazard ratio.88, 95% confidence interval.78–1.00, P <.05) compared with the reference group (<1.06). Besides, splines showed the relationship was nonlinear (P <.05) and the inflection point was 1.11. In conclusion, the level of ABI associated with the lowest risk of all-cause mortality was 1.11, under which a lower ABI was independently associated with an increased risk of all-cause mortality. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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