15 results on '"*ANKLE brachial index"'
Search Results
2. The Relationship Between Serum Bilirubin Levels and Peripheral Arterial Disease and Gender Difference in Patients With Hypertension: BEST Study.
- Author
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Lan, Yang, Liu, Huan, Liu, Jinbo, Zhao, Hongwei, and Wang, Hongyu
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BILIRUBIN , *CARDIOVASCULAR diseases risk factors , *CONFIDENCE intervals , *FASTING , *HYPERTENSION , *OXIDATION-reduction reaction , *PERIPHERAL vascular diseases , *RISK assessment , *SEX distribution , *VANADATES , *ANKLE brachial index , *ODDS ratio , *DISEASE risk factors - Abstract
We evaluated the relationship between serum bilirubin levels and ankle-brachial index (ABI) to determine whether gender affected the relationship between bilirubin levels and peripheral arterial disease (PAD) in patients with hypertension. A total of 543 patients were included in our studies (78 patients with PAD and 465 without PAD). Peripheral arterial disease was defined as ABI <0.90 for either and/or both sides. Serum bilirubin levels were measured with a vanadate oxidation method by using fasting venous blood samples. Serum total bilirubin (TBiL) and direct bilirubin (DBiL) levels were higher in males compared with females (both P <.05). Total bilirubin and DBiL were significantly lower in the PAD group. After adjustment for cardiovascular risk factors, PAD was independently negatively related to TBiL and DBiL, with odds ratios (OR) 0.914 (95% confidence interval [CI]: 0.845-0.990) and 0.748 (95% CI: 0.572-0.977). In addition, there was a relationship between PAD and bilirubin levels (TBiL—OR = 0.884, 95% CI: 0.792-0.985; DBiL—OR = 0.621; 95% CI: 0.424-0.909) only in males but not in females. Future studies should further evaluate whether interventions that increase serum bilirubin levels will have a particular role in PAD prevention in males. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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3. A Targeted Literature Review of the Disease Burden in Patients With Symptomatic Peripheral Artery Disease.
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Bauersachs, Rupert, Debus, Sebastian, Nehler, Mark, Huelsebeck, Maria, Balradj, Janita, Bowrin, Kevin, and Briere, Jean-Baptiste
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PERIPHERAL vascular disease treatment , *ANGIOGRAPHY , *CARDIOVASCULAR diseases risk factors , *CARDIOVASCULAR surgery , *ECONOMIC aspects of diseases , *EXERCISE tests , *EXERCISE therapy , *EXTREMITIES (Anatomy) , *MEDICAL information storage & retrieval systems , *MEDLINE , *PERIPHERAL vascular diseases , *QUALITY of life , *SURVIVAL , *SYSTEMATIC reviews , *TETRAZOLES , *DISEASE incidence , *DISEASE prevalence , *ANKLE brachial index , *PLATELET aggregation inhibitors ,PERIPHERAL vascular disease diagnosis ,MORTALITY risk factors - Abstract
Patients with peripheral artery disease (PAD) have an increased risk of cardiovascular (CV) and limb events, but the disease is frequently underdiagnosed and treatment options are limited. This review examines the disease burden of symptomatic PAD as well as key guideline recommendations. Publications were identified using the ProQuest portal to access the Medline, Medline In-Process, and Embase databases. Search terms for symptomatic PAD were combined with terms relevant to epidemiology, burden, treatment practice, and physiopathology. Articles in English published between January 2001 and September 2016 were screened according to the population, interventions, comparator, outcomes, and study design criteria. Relevant publications (n = 200) were identified. The reported incidence and prevalence of PAD varied depending on the definitions used and the study populations. Patients generally had a poor prognosis, with an increased risk of mortality, CV, and limb events and decreased quality of life. Guideline recommendations included ankle–brachial index measurements, exercise testing, and angiography for diagnosis and risk factor modification, antiplatelets, cilostazol, exercise therapy, or surgical interventions for treatment, depending on the patient profile. The clinical, humanistic, and economic burden of disease in patients with symptomatic PAD is substantial and needs to be reduced through improved PAD management. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Evaluation of Risk Factors for Limb-Specific Peripheral Vascular Events in Patients With Peripheral Artery Disease: A Post Hoc Analysis of the SEASON Prospective Observational Study.
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Miyata, Tetsuro, Higashi, Yukihito, Shigematsu, Hiroshi, Origasa, Hideki, Fujita, Masatoshi, Matsuo, Hiroshi, Naritomi, Hiroaki, Matsuda, Hiroaki, Nakajima, Masahide, Yuki, Satoshi, and Awano, Hideto
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AMPUTATION , *CARDIOVASCULAR diseases risk factors , *CHRONIC kidney failure , *CONFIDENCE intervals , *DIABETES , *EXTREMITIES (Anatomy) , *LONGITUDINAL method , *SCIENTIFIC observation , *PERIPHERAL vascular diseases , *STATISTICS , *DATA analysis , *PROPORTIONAL hazards models , *ANKLE brachial index , *DISEASE risk factors - Abstract
Surveillance of cardiovascular Events in Antiplatelet-treated arterioSclerosis Obliterans patients in JapaN (SEASON) is a 2-year, prospective, real-world, registry study conducted in Japan from 2009 to 2013. This post hoc analysis evaluated risk factors for limb ischemia in patients with peripheral arterial disease (PAD) and ankle–brachial index (ABI) <0.90. Vascular events were adjudicated by an Efficacy Endpoint Review Committee. Cox regression identified predictors of limb-specific peripheral vascular events (amputation, development of critical limb ischemia, and acute limb ischemia). Patients (n = 6565) were stratified according to ABI: normal (≥1.0; n = 1300), borderline (0.90 ≤ ABI ≤ 1.0; n = 776), and abnormal (<0.90; n = 4489). Compared to normal ABI, patients with ABI <0.90 had a significantly higher risk of any vascular event, all-cause death, and any limb-specific peripheral vascular event. Risk factors for limb-specific vascular events included history of lower extremity revascularization/amputation (adjusted hazard ratio: 2.18; 95% confidence interval [CI]: 1.49-3.20), chronic kidney disease (2.00; 1.33-3.00), diabetes (1.71; 1.16-2.52), and ABI <0.4 (4.45; 2.62-7.55) or <0.7 (1.78; 1.15-2.76). These findings from a Japanese real-world population confirm the increased vascular risk of patients with PAD and ABI <0.90 and identified risk factors for limb-specific peripheral vascular events. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Triglyceride Glucose Index Was Associated With the Risk of Peripheral Artery Disease: Reply.
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Liu, Yihai, Chang, Lei, Wu, Mingyue, Xu, Biao, and Kang, Lina
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TRIGLYCERIDES , *BIOMARKERS , *LIFESTYLES , *CARDIOVASCULAR diseases risk factors , *ANKLE brachial index , *PERIPHERAL vascular diseases , *BLOOD sugar , *SOCIODEMOGRAPHIC factors , *DISEASE risk factors - Published
- 2023
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6. The Ankle-Brachial Index is Associated With Cardiovascular Complications After Noncardiac Surgery.
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Carmo, G. A., Calderaro, D., Gualandro, D. M., Pastana, A. F., Yu, P. C., Marques, A. C., and Caramelli, B.
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ACADEMIC medical centers , *ATHEROSCLEROSIS , *CARDIAC arrest , *CARDIOVASCULAR diseases , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CLINICAL trials , *CONFIDENCE intervals , *DEATH , *FISHER exact test , *HEART failure , *LONGITUDINAL method , *EVALUATION of medical care , *PATIENTS , *PERIPHERAL vascular diseases , *PULMONARY edema , *RESEARCH funding , *RISK assessment , *STATISTICAL sampling , *STATISTICS , *STROKE , *SURGERY , *SURGICAL complications , *OPERATIVE surgery , *T-test (Statistics) , *LOGISTIC regression analysis , *JUDGMENT sampling , *CONTROL groups , *ANKLE brachial index , *ACUTE coronary syndrome , *TROPONIN , *DESCRIPTIVE statistics , *ODDS ratio , *MANN Whitney U Test - Abstract
Background: This study evaluated the association of the ankle-brachial index (ABI) and cardiovascular complications after noncardiac surgery. Methods: We prospectively evaluated patients referred for noncardiac surgery. The ABI was performed before surgery. Patients with abnormal ABI (≤0.9) were included in the peripheral artery disease (PAD) group and the remaining constituted the control group. Cardiac troponin and electrocardiogram were obtained 72 hours after surgery. Patients were followed up to 30 days, and primary end point was the occurrence of any cardiovascular event: cardiovascular death, acute coronary syndrome, isolated troponin elevation (ITE), decompensated heart failure, cardiogenic shock, unstable arrhythmias, nonfatal cardiac arrest, pulmonary edema, stroke, or PAD symptoms increase. Results: We evaluated 124 patients (61.3% male; mean age 65.4 years). During the study, 57.9% of patients in the PAD group had an event versus 25.7% in the control group (P = .011). The ITE was the most observed event (24.2%). After logistic regression, the odds ratio for ITE was 7.4 (95% confidence interval 2.2-25.0, P = .001). Conclusions: In patients submitted to noncardiac surgery, abnormal ABI is associated with a higher occurrence of a cardiovascular event. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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7. Earlobe Crease May Provide Predictive Information on Asymptomatic Peripheral Arterial Disease in Patients Clinically Free of Atherosclerotic Vascular Disease.
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Korkmaz, Levent, Ağaç, Mustafa Tarık, Acar, Zeydin, Erkan, Hakan, Gurbak, Ismail, Kurt, Ibrahim Halil, Bektas, Huseyin, Pelit, Erdinc, Korkmaz, Ayca Ata, and Çelik, Şükrü
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EXTERNAL ear , *ACADEMIC medical centers , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CONFIDENCE intervals , *CUTANEOUS manifestations of general diseases , *MULTIVARIATE analysis , *PERIPHERAL vascular diseases , *T-test (Statistics) , *U-statistics , *LOGISTIC regression analysis , *ANKLE brachial index , *DATA analysis software , *DESCRIPTIVE statistics , *PHYSIOLOGY - Abstract
The diagonal earlobe crease (ELC) has been regarded as a simple marker of atherosclerosis. There is no knowledge concerning the relation of ELC to the presence, extent, and severity of peripheral arterial disease (PAD). Patients (n = 253) without known atherosclerotic vascular disease and symptoms were enrolled consecutively. Ankle brachial index (ABI) was measured. Patients with ELC had lower ABI compared to those with no ELC (1.02 ± 0.12 vs 1.11 ± 0.08, P < .001). Multivariate analysis demonstrated ELC (95% confidence interval [CI]: 3.3-21.9; P: .001) and age (95% CI: 0.87-0.99; P = .02) as independent determinants of abnormal ABI. There was incremental increased frequency of ELC from normal ABI to significant PAD. We have shown for the first time a significant and independent association between presence of ELC and increased prevalence, extent, and severity of PAD in patients without overt atherosclerotic vascular disease. [ABSTRACT FROM PUBLISHER]
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- 2014
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8. Prevalence of Low Ankle Brachial Index and Relationship With Cardiovascular Risk Factors in a Western Urban Population in Turkey.
- Author
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Sözmen, Kaan and Ünal, Belgin
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CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CONFIDENCE intervals , *EPIDEMIOLOGY , *INTERVIEWING , *PERIPHERAL vascular diseases , *QUESTIONNAIRES , *U-statistics , *CITY dwellers , *LOGISTIC regression analysis , *DATA analysis , *DISEASE prevalence , *CROSS-sectional method , *ANKLE brachial index , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
We determined the prevalence of peripheral arterial disease (PAD) and associated risk factors in an urban population age ≥30 years in Turkey and assessed the impact of incorporating ankle brachial index (ABI) measurement with coronary heart disease risk calculations to the risk reclassification of individuals. The sample was drawn from 4600 participants of Balcova Heart Study. The prevalence of low ABI (<0.9) was 6.3%. Current smoking (odds ratio [OR]: 5.07, 95% confidence interval [CI]: 1.85-13.88), cardiovascular disease history (OR: 6.83, 95% CI: 3.00-15.53), hypertension (OR: 2.58, 95% CI: 1.06-6.33), diabetes (OR: 3.25, 95% CI: 1.51-6.98), and high waist circumference (OR: 2.24, 95% CI: 1.02-4.94) were positively associated with prevalent PAD. When ABI measurement was taken into account, 3.5% of low or intermediate risk patients were reclassified as high risk. Screening individuals who have one of these risk factors with ABI can help reclassifying individuals toward the high-risk category. [ABSTRACT FROM PUBLISHER]
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- 2014
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9. Relation Between Aortic Valve Sclerosis and Ankle–Brachial Index in Participants Clinically Free of Atherosclerotic Vascular Disease.
- Author
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Korkmaz, Levent, Ağaç, Mustafa Tarık, Bektas, Huseyin, Varol, Mustafa Oguz, Erkan, Hakan, Acar, Zeydin, Kurt, Devrim, and Çelik, Şükrü
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PERIPHERAL vascular diseases , *AORTIC stenosis , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CONFIDENCE intervals , *STATISTICAL correlation , *REGRESSION analysis , *STATISTICS , *T-test (Statistics) , *U-statistics , *DATA analysis , *ANKLE brachial index , *DATA analysis software , *DESCRIPTIVE statistics , *DISEASE risk factors - Abstract
Most patients with peripheral arterial disease (PAD) are asymptomatic and have similar vascular morbidity and mortality with patients with symptomatic PAD. Despite being a very highly prevalent disease, physicians underdiagnose and undertreat PAD. A total of 100 participants with aortic valve sclerosis (AVS) and 100 participants without AVS and age-, gender-, and cardiovascular risk factor–matched participants were enrolled. Ankle–brachial index (ABI) and AVS were evaluated by handheld Doppler device and echocardiography, respectively. There was significantly lower ABI in participants with AVS compared with those without AVS (1.04 ± 0.14 v 1.11 ± 0.07, P = .001). There was a negative correlation between ABI and AVS (r = −.29, P < .001). Linear regression analysis demonstrated an independent association between ABI and AVS (95% confidence interval [CI]: −0.91 to −0.27, P < .001) and β-blocker use (95% CI: −0.96 to −0.02, P: .04). Our findings confirm an association between AVS and PAD that may be attributed to shared vascular risk factors. [ABSTRACT FROM PUBLISHER]
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- 2013
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10. Ankle Brachial Pressure Index: Faulty or Overused?
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Manfredini, Fabio, Malagoni, Anna Maria, and Manfredini, Roberto
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MEDICAL screening , *DOPPLER ultrasonography , *CARDIOVASCULAR diseases risk factors , *NEAR infrared spectroscopy , *PERIPHERAL vascular diseases , *PLETHYSMOGRAPHY , *PRIMARY health care , *ANKLE brachial index - Abstract
The article discusses the ankle–brachial pressure index (ABPI) method which is useful in detecting peripheral arterial disease (PAD). The systolic blood pressure (SBP) of the posterior tibial and dorsalis pedis arteries of each leg with the higher brachial pressure of either arm are compared to measure ABPI. Patients with arterial calcification and incompressible arteries ABPI is less effective. It is also discussed that measurement of ABPI should be improved.
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- 2013
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11. Low Estimated Glomerular Filtration Rate Is a Major Determinant of Low Ankle-Brachial Index and Toe-Brachial Index in Type 2 Diabetes.
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Sheen, Yi-Jing, Lin, Jainn-Liang, Lee, I-Te, Hsu, Yuan-Nian, Li, Tsai-Chung, and Sheu, Wayne Huey-Herng
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ATHEROSCLEROSIS risk factors , *AGE distribution , *ANALYSIS of covariance , *ANALYSIS of variance , *BIOMARKERS , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CONFIDENCE intervals , *STATISTICAL correlation , *PEOPLE with diabetes , *EPIDEMIOLOGY , *EXERCISE , *GLOMERULAR filtration rate , *TYPE 2 diabetes , *PERIPHERAL vascular diseases , *REGRESSION analysis , *KIDNEY failure , *RESEARCH funding , *SEX distribution , *STATISTICS , *T-test (Statistics) , *TOES , *DATA analysis , *MULTIPLE regression analysis , *CROSS-sectional method , *RETROSPECTIVE studies , *ANKLE brachial index , *DATA analysis software , *DESCRIPTIVE statistics ,PERIPHERAL vascular disease diagnosis - Abstract
We enrolled 1461 Taiwanese type 2 diabetic outpatients with ankle-brachial index (ABI) and toe-brachial index (TBI) examinations, excluding participants with history of stroke, end-stage renal disease, malignancy, acute myocardial infarction, amputation, and overt calcification of the lower limbs (ABI >1.3). Ankle-brachial index values <0.9 were found in 2.8% of the patients and 5.7% had TBI <0.6. Estimated glomerular filtration rate (eGFR; 90 ± 33 mL/min per 1.73 m2) obtained from 473 patients correlated significantly with both ABI and TBI. Progressive eGFR decline was observed in 419 participants with normal ABI and TBI, 35 with normal ABI but low TBI, and 19 with low ABI and normal or low TBI (P for trend <.001). After adjusting for confounding factors, age and eGFR were significantly associated with TBI and ABI. Low eGFR is associated with peripheral arterial disease in type 2 diabetes with mild to moderate renal insufficiency. [ABSTRACT FROM PUBLISHER]
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- 2012
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12. Do Novel Risk Biomarkers Reflect the Severity of Peripheral Arterial Disease?
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Khandanpour, Nader, Jennings, Barbara, Armon, Matthew P., Wright, Anthony, Willis, Gavin, Clark, Allan, and Meyer, Felicity J.
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ACADEMIC medical centers , *ANALYSIS of variance , *ANISOTROPY , *BIOMARKERS , *BLOOD coagulation factors , *C-reactive protein , *CARDIOVASCULAR diseases risk factors , *FLUORIMETRY , *INFLAMMATORY mediators , *INTERLEUKINS , *PERIPHERAL vascular diseases , *RESEARCH funding , *STATISTICS , *HOMOCYSTEINE , *LOGISTIC regression analysis , *DATA analysis , *MULTIPLE regression analysis , *ANKLE brachial index ,PERIPHERAL vascular disease diagnosis - Abstract
The association between novel atherosclerotic risk biomarkers and severity of peripheral arterial disease (PAD) was assessed. Patients (n = 133) with PAD were recruited. Established risk biomarkers including low- and high-density cholesterol, triglycerides, and blood pressure were measured. Novel risk biomarkers including plasma C-reactive protein, von Willebrand factor (vWF), interleukin 6, red cell folate (RCF), vitamin B12, total homocysteine (tHcy), and Hcy genotypes were also determined. The severity of PAD was evaluated, using ankle—brachial pressure index (ABPI), brachial—knee, and brachial—ankle pulse wave velocity (bk- and ba-PWV). Plasma tHcy and systolic blood pressure had a positive independent correlation with bk-PWV (β = +0.56, P = .02 and β = +0.38, P < .001, respectively). Red cell folate had an independent inverse correlation with bk-PWV (β = —0.01, P = .01). Systolic blood pressure showed an independent positive correlation with ba-PWV only after adjustment for other risk biomarkers (β = +0.1, P = .04). Novel markers, plasma tHcy, and RCF levels correlated with the severity of PAD. [ABSTRACT FROM PUBLISHER]
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- 2011
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13. The Role of Postexercise Measurements in the Diagnosis of Peripheral Arterial Disease in HIV-Infected Patients.
- Author
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Qaqa, Ashraf Y., DeBari, Vincent A., Isbitan, A., Mohammad, N., Sison, R., Slim, Jihad, Perez, George, and Shamoon, Fayez E.
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HIV infection complications , *ANALYSIS of variance , *CARDIOVASCULAR diseases risk factors , *EXERCISE , *EXERCISE tests , *FISHER exact test , *HIV-positive persons , *LONGITUDINAL method , *PERIPHERAL vascular diseases , *SEX distribution , *STATISTICAL hypothesis testing , *T-test (Statistics) , *U-statistics , *DISEASE prevalence , *RECEIVER operating characteristic curves , *ANKLE brachial index ,PERIPHERAL vascular disease diagnosis - Abstract
Peripheral arterial disease (PAD) is a marker of atherosclerosis, which is not well studied in the population with human immunodeficiency virus (HIV). We prospectively enrolled HIV-infected patients who had normal resting ankle-brachial index (rABI) readings. All participants performed either a treadmill walking test (TT) or pedal plantar flexion test (PFT). Patients were divided into 2 groups according to postexercise changes; PAD and No-PAD group. The 2 groups were compared with regard to established cardiovascular disease risk factors and other HIV infection parameters. Peripheral arterial disease was present in 30 (26.5%) of 113 consecutive HIV-infected patients included in the study. Mean age was 47 ± 10 years. The risk factors studied did not differ significantly among the 2 groups except for male gender, which was significantly associated with PAD (RR: 4.15; CI: 1.6 to 11.1: P < .0008). The prevalence of PAD, diagnosed by significant drop in postexercise ABI and ankle pressure in patients with HIV is high. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
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14. Relationship Between Noninvasively Measured Endothelial Function and Peripheral Arterial Disease.
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Maldonado, Francisco José Medina, Miralles, Joaquín de Haro, Aguilar, Esther Martínez, Gonzalez, Aurora Florez, García, Jose Ramón March, and García, Francisco Acín
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PERIPHERAL vascular diseases , *VASCULAR endothelium , *BRACHIAL artery , *CARDIOVASCULAR diseases risk factors , *ANKLE brachial index - Abstract
Objectives: To determine the relationship between endothelial function by means of brachial artery flow-mediated dilation (BAFMD) and the clinical severity of peripheral arterial disease (PAD). Methods and Results: We examined the brachial artery diameter by ultrasound, before and after ischemia of the arm in 3 groups of participants-- group A: healthy individuals under 30 years, without cardiovascular risk factors (n = 30); group B: patients with PAD and ischemic claudication (n = 30); and group C: patients with critical leg ischemia (n = 20). There were no differences between groups B and C, in regard to age, sex, and main cardiovascular risk factor. The BAFMD was 9.9% in group A compared with 5.5% in the pooled patients group (B þ C; P < .001). Significant differences were absent between groups B and C (P > .05). Correlation coefficient of ankle-brachial index/BAFMD was r = .1; P = .49. Conclusions: Patients with PAD present endothelial dysfunction, but this does not seem to determine the severity of the disease. [ABSTRACT FROM AUTHOR]
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- 2009
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15. Only Ankle-Brachial Index May Not Be an Accurate Information About the Prevalence of Peripheral Arterial Disease.
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Balta, Sevket, Demirkol, Sait, Yesil, Fahri Gurkan, Cakar, Mustafa, Sarlak, Hakan, and Celik, Turgay
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CARDIOVASCULAR diseases risk factors , *PERIPHERAL vascular diseases , *ANKLE brachial index ,PERIPHERAL vascular disease diagnosis - Abstract
A letter to the editor is presented in response to the article "Peripheral arterial disease is prevalent but underdiagnosed and undertreated in the primary care setting in central Greece" by C. Argyriou and colleagues in a 2013 issue of the periodical.
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- 2013
- Full Text
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