1. The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography.
- Author
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Cury MVM, Matielo MF, Brochado Neto FC, Soares RA, Adami VL, Morais JDF, Futigami AY, and Sacilotto R
- Subjects
- Acute Kidney Injury physiopathology, Aged, Aged, 80 and over, Brazil epidemiology, Female, Glomerular Filtration Rate, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors, Survival Rate, Acute Kidney Injury chemically induced, Acute Kidney Injury epidemiology, Angiography, Digital Subtraction adverse effects, Contrast Media adverse effects, Ischemia diagnostic imaging, Lower Extremity blood supply, Lower Extremity diagnostic imaging
- Abstract
Intra-arterial digital subtraction angiography (DSA) is commonly used for the diagnosis and treatment of patients with critical limb ischemia (CLI). The aim of this study was to analyze the incidence of contrast-induced nephropathy (CIN) in patients with CLI and to assess their outcomes. Between May 2013 and May 2014, a prospective and observational study was conducted with 107 patients admitted exclusively for CLI treatment. The main outcomes included hemodialysis independence (HI) and overall survival (OS), as assessed by Kaplan-Meier curves. Overall, there was a predominance of males (57%), with a mean age of 70.5 (10.7) years. The incidence of CIN was 35.5%, and chronic kidney failure was the only factor associated with elevated risk of this condition (relative risk [RR] = 1.9; 95% confidence interval = 1.17-3.09; P = .017). The median follow-up was 645 days, and in 720-day analyses, patients who experienced CIN had worse HI (81.2% vs 96.3%; P = .0107) and OS (49.5% vs 66.3%; P = .0463). The current study found a high incidence of CIN in patients with CLI after DSA. This renal impairment was associated with a worse prognosis in terms of survival.
- Published
- 2018
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