1. Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis.
- Author
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Xu H, Wang H, Zhang C, Xiao J, Hua N, Tang X, Xie J, and Zhang Z
- Subjects
- Acute Kidney Injury chemically induced, Acute Kidney Injury diagnosis, Alprostadil adverse effects, Combined Modality Therapy, Female, Fluid Therapy, Humans, Male, Middle Aged, Protective Agents adverse effects, Protective Factors, Risk Assessment, Risk Factors, Treatment Outcome, Acute Kidney Injury prevention & control, Alprostadil therapeutic use, Contrast Media adverse effects, Coronary Angiography adverse effects, Protective Agents therapeutic use
- Abstract
This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 µg/d alprostadil or 20 µg/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 µg/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.
- Published
- 2021
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