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Simple Summary: This work aims to analyze flocks' management practices and sheep breeders' perceptions of the impact of climate change to enhance the resilience of the sheep production systems in the Tunisian semi-arid region. The results revealed three main sheep production systems: the agro-pastoral rain-fed system (AGPRF), the agro-pastoral irrigated system (AGPI), and the agro-sylvo-pastoral system (AGSP). Each production system is characterized by specific management and productive parameters that are used by farmers to build resilience actions. However, farmers' climate change perceptions are mostly the same across the three sheep production systems: a decrease in precipitation and an increase in temperatures and extreme events, which negatively influence feedstuff availability and costs. Global climate change inflicts unambiguous risks on agricultural systems and food security. Small ruminants are known for their ability to adapt to changing environmental conditions. This paper aims to characterize sheep production systems in a vulnerable agricultural zone and the breeders' perceptions of climate change to apprehend challenges that they are confronting, and formulate resilience actions. The data analysis is based on 94 semi-structured surveys of sheep farmers carried out in the Tunisian semi-arid region. The PCA analysis results revealed three main sheep production systems. The agro-pastoral rain-fed system (AGPRF) is dominant (55%), with large farms and common pastures integrating cereals and fodder. The agro-pastoral irrigated system (AGPI: 20%) is characterized by small-area and forage irrigation (1.8 ha) and a smaller number of ewes but a greater use of animal feed supplementation. The agro-sylvo-pastoral system (AGSP: 25%) is a system where grazing is based on common lands and using tree sub-products, while the agricultural area is exclusively used to cultivate cereal crops. Sheep breeders' climate perceptions are summarized as unpredictable climate events, a decrease in precipitation, and an increase in temperature. Resilience actions principally consist of reducing flocks' numbers, using alternative local feed, fodder, and water resources, and building more shelters and planting more trees in the grazing areas. Nevertheless, cost-effectiveness should be considered in such vulnerable zones to insure the sheep production systems' sustainability. [ABSTRACT FROM AUTHOR]