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INTRODUCTION: A hypercoagulability status has been reported in SARS-CoV-2 infection. Beside their traditional roles, platelets are referred to as immune cells. The purpose of the study was to examine platelet activation and aggregation in COVID-19. METHODS: This case-control study comprised 61 patients with SARS-CoV-2 infection and 18 healthy individuals. The patients were separated into groups with respect to the need for treatment in the intensive care unit (ICU). CD41, CD61, CD42a, and CD42b were determined as platelet activation markers, and platelet aggregation tests were analyzed in all groups. RESULTS: Platelet CD41, CD61, CD42a, and CD42b expressions were significantly elevated in ICU patients compared to non-ICU patients and healthy donors. Patients in the ICU group had increased platelet aggregations than those in non-ICU patients and controls. Additionally, platelet activation and platelet function tests correlated with inflammatory and coagulation markers involving C‐reactive protein, Interleukin-6, neutrophil-to-lymphocyte ratio, platelet‐to‐lymphocyte ratio, monocyte to lymphocyte ratio, D-dimer, and fibrinogen concentrations. DISCUSSION AND CONCLUSION: Enhanced platelet activity and faster platelet aggregation were observed in ICU COVID-19 patients. It is possible that platelet hyperreactivity may contribute to the progression of SARS-CoV-2 infection. The relationships between platelet activation and functions tests with inflammatory and coagulation markers show that systemic inflammation and cytokines may trigger the hypercoagulability in COVID-19 patients in ICU, or hyperactivated platelets could augment the inflammation.

INTRODUCTION: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD). METHODS: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AAD on computed tomography of the thorax were retrospectively reviewed. There were two groups in the study, one AAD group, and the other healthy volunteers' group. First, thiol and disulfide levels were determined with the spectrophotometric method defined by Erel and Neşelioğlu, natural thiol (NT), total thiol (TT), and disulfide (D) levels, and their ratios were calculated (index 1: D / NT, index 2: D / TT, index 3: NT / TT). We compared these two groups in terms of Oxidative stress parameters. RESULTS: A total of 40 patients with AAD and 38 age-matched healthy volunteers were included in this study. There was no significant difference between the two groups in terms of gender and age (p=0.923, p=0.401, respectively). The AAD group had significantly lower natural thiol and total thiol (p

INTRODUCTION: The thiol-disulphide (TDH) homeostasis was investigated in a number of disorders. The aim of the present study is to investigate the dynamic thiol-disulphide homeostasis in patients diagnosed with obstructive jaundice and to compare the dynamic thiol-disulphide homeostasis with ischemia-modified albumin. METHODS: A total of 146 participants who were admitted to the emergency department and who consisted of 69 patients and 77 healthy volunteers were included in the study. Detailed blood samples were obtained from the patients at the time of admission. Thiol/disulphide levels were examined using a brand-new method developed by Erel and Neselioglu on the patients diagnosed with obstructive jaundice during the admission. Data were evaluated in the computer system. RESULTS: The levels of total thiol (p =0.025) and native thiol (p =0.023) were statistically significantly lower in the patient with obstructive jaundice than in the control group. It was observed that there was a significant negative correlation between the native thiol levels and the ALP (r =-0.262, p

Amaç: Bu çalışmanın amacı acil servise renal kolik nedeniyle başvuran hastalarda oksidatif stresmarkerlarından olan tiyol/disülfid homeostazı parametreleri ile Nötrofil‐Lenfosit ve Platelet‐Lenfositoranlarının (NLO, PLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır.Materyal ve Metot: Çalışma 15.05.2018 ile 01.10.2018 tarihleri arasında acil servise başvuran ve çalışmayaalınan 75 hasta ve kontrol grubu olarak belirlenen 47 sağlıklı kişi ile prospektif olarak yapıldı. Erel veNeşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres belirteci olan tiyol/disülfid homeostazparametreleri ( Tiyol, disülfid, disülfid / native tiyol, disüfid / total tiyol, native tiyol / total tiyol) ile NLOve PLO hasta ve kontrol grubunda çalışıldı. Üriner taş hastalığı olan ve olmayanlar arasında buparametreler karşılaştırıldı.Bulgular: Renal koliği olanlarda kontrol grubuna göre, NLO, PLO, disülfid, disülfid /native tiyol vedisülfid /total tiyol ortalama değerleri anlamlı derecede yüksek bulunurken (sırasıyla p= 0.010,