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Spiradiclis cavicola L. Wu, Hareesh & B. Pan (Rubiaceae), a new species from limestone caves in Guizhou and Guangxi provinces, southwestern China, is described and illustrated. It is morphologically similar to S. scabrida, but can be easily distinguished by its 0.5-3 cm long petiole, elliptic to oblong leaf blade, and homostylous flowers with anthers and stigma positioned at the throat of corolla tube, or sometimes stigma slightly above anthers. [ABSTRACT FROM AUTHOR]