1. Acquired Pelger-Huët anomaly/abnormal chromatin clumping of granulocytes after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia: medication or relapse?
- Author
-
Aline Schmidt, Anna Zharkova, Marc Zandecki, Laurane Cottin, Iris Henriot, Bénédicte Ribourtout, Jean-Maxime Girard, Aurélien Sutra Del Galy, and Pierre Daufresne
- Subjects
Pathology ,medicine.medical_specialty ,Transplantation Conditioning ,Drug-Related Side Effects and Adverse Reactions ,medicine.medical_treatment ,Early Relapse ,Hematopoietic stem cell transplantation ,Granulocyte ,Diagnosis, Differential ,Recurrence ,Humans ,Transplantation, Homologous ,Medicine ,business.industry ,Hematopoietic Stem Cell Transplantation ,Myeloid leukemia ,General Medicine ,Middle Aged ,medicine.disease ,Chromatin ,Leukemia, Myeloid, Acute ,medicine.anatomical_structure ,Immunology ,Cyclosporine ,Pelger–Huet anomaly ,Female ,Myeloid leukaemia ,Stem cell ,Pelger-Huet Anomaly ,business ,Granulocytes - Abstract
An acute myeloid leukemia was diagnosed in a 53-year-old female patient. She received an allogeneic stem cell transplant. After this transplant, some neutrophils with hyposegmented nucleus and abnormal chromatin clumping appeared in the peripheral blood, and their number gradually increased. The hypothesis of early relapse after transplant was ruled out and drug-related anomaly was suspected. The authors discuss about morphological features of constitutional and acquired Pelger-Huët anomaly. In the patient reported here, ciclosporine seemed to be involved in the phenomenon, as the morphological anomaly of the neutrophils gradually decreased after the drug was discontinued.
- Published
- 2016
- Full Text
- View/download PDF