1. About a case of macro-FSH analytical interference
- Author
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Claire Guibet, Alizée Violin, Jean-Benoît Corcuff, Agnès Georges, Julie Brossaud, Virginie Grouthier, and Cindy Lauro
- Subjects
endocrine system ,Adolescent ,media_common.quotation_subject ,Physiology ,Antibodies, Heterophile ,Interference (genetic) ,Mice ,Animals ,Humans ,Medicine ,Pathological ,Menstrual cycle ,Autoantibodies ,media_common ,biology ,business.industry ,Ovarian failure ,Autoantibody ,General Medicine ,medicine.disease ,University hospital ,Premature ovarian failure ,biology.protein ,Female ,Follicle Stimulating Hormone ,Antibody ,business - Abstract
An 18-year-old woman was referred by her GP to the endocrinology department of the University Hospital of Bordeaux on suspicion of premature ovarian failure because of a disorder of the menstrual cycle and pathological results of biological exploration of the gonadotropic axis. Repeatedly-found elevated concentrations of FSH contrasted with a normal concentration of LH leading to a hypothesis of ovarian failure. However, different investigations favoured an analytical interference. The presence of heterophilic antibodies or anti-mouse antibodies (HAMA) was unlikely but, finally, a complex combining FSH and autoantibody (called macro-FSH) was evidenced.
- Published
- 2021