1. How to interpret cardiac biomarkers in renal failure and elderly?
- Author
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Bargnoux AS, Kuster N, Moréna M, Baptista G, Chenine L, Badiou S, Leray H, Dupuy AM, and Cristol JP
- Subjects
- Age Factors, Aged, Aged, 80 and over, Heart physiopathology, Humans, Myocardial Infarction diagnosis, Renal Insufficiency diagnosis, Renal Insufficiency physiopathology, Troponin I metabolism, Troponin T metabolism, Biomarkers metabolism, Myocardium metabolism, Renal Insufficiency metabolism
- Abstract
New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn) as markers of injury while natriuretic peptides remain the markers of choice for myocardial dysfunction. However, variability extracardiac factors such as age, gender and renal function may alter circulating levels. In chronic kidney disease (CKD), the increase in circulating levels of these biomarkers in the absence of cardiac disease underlines the problem of discriminative value for diagnosis as well as the need to redefine the thresholds. In addition, these biomarkers are of potential interest to stratify cardiovascular risk, the leading cause of death in CKD. The aim of this work is to clarify the effect of age and renal function on circulating levels of high-sensitivity troponins and natriuretic peptides.
- Published
- 2016
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