1. HLA non-class II genes may confer type I diabetes susceptibility in a mapuche (Amerindian) affected family
- Author
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Silvia Asenjo, J. Zamora, Juan Moscoso, Antonio Arnaiz-Villena, Jorge Martinez-Laso, Juan Ignacio Serrano-Vela, José Manuel Martín-Villa, Almudena Moreno, Francisco Pérez-Bravo, and Andrea Gleisner
- Subjects
Adult ,Genetic Markers ,Male ,Glutamate decarboxylase ,Type 2 diabetes ,Human leukocyte antigen ,Biology ,Linkage Disequilibrium ,Genetic determinism ,Gene Frequency ,Diabetes mellitus ,medicine ,Genetics ,Humans ,Genetic Predisposition to Disease ,Child ,Gene ,Genetics (clinical) ,Type 1 diabetes ,Class (computer programming) ,Indians, South American ,Siblings ,Autoantibody ,HLA-DR Antigens ,General Medicine ,medicine.disease ,Pedigree ,Diabetes Mellitus, Type 1 ,Haplotypes ,Immunology ,Type i diabetes ,Female - Abstract
A rare case of type I diabetes is studied in an Amerindian (Mapuche) family from Chile, analyzing glutamic acid decarboxylase, islet-cell autoantibodies and human leukocyte antigen (HLA) genes. The affected sib is the only one that has one specific HLA haplotype combination that differs from the other sibs only in the HLA class I genes. It is concluded that HLA diabetes susceptibility factors may be placed outside the class II region or even that susceptibility factors do not exist in the HLA region in this Amerindian family.
- Published
- 2004
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